Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped

Early Phase 1UnknownNCT04950205

Second Affiliated Hospital, School of Medicine, Zhejiang University140 enrolled

Overview

Brief summary: In order to get a better clinical plan for brain protection during perioperative anesthesia for high-risk patients - carotid intima stripped. We observing the hemodynamic changes of sevoflurane post-treatment in carotid intima stripped, the comparison of postoperative cognitive function and postoperative radiographic changes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

140

Conditions

Postoperative Cognitive Dysfunction Sevoflurane Carotid Artery Intima Stripped

Interventions

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists（ASA）：II-III * Aged between 40 and 80 years * Patients scheduled for surgery of Carotid stenosis under general anaesthesia Exclusion Criteria: * Has a history of mental illness can't cooperate, * Serious heart block or cardiac decompensation or severe sinus slow (HR \< 50 times/min), * The abnormal nerve monitoring in operation, MMES preoperative score \< 20 points, * Any rescue unexpected occurred during the operation

Locations (2)

2nd Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

RECRUITING

2nd Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

RECRUITING

Outcomes

Primary Outcomes

Change from the 1 day preoperative to the 1 day postoperative MMSE(Mini-mental State Examination)

Screening scale of cognitive function。The highest score is 30 points, 27 to 30 were divided into normal, less than 27 divided into cognitive dysfunction。But is not sensitive in the early identification of dementia, especially in mild cognitive impairment is poorer.

Time frame: the 1st day before the surgery；the 1st day after the surgery

Change from the 1 day preoperative to the 1 day postoperative MoCA(Montreal Cognitive Assessment)

Screening scale of cognitive function。The highest score is 30 points，Add 1 score, education the following subjects in less than 12 years。Total score less than 26 divided into cognitive dysfunction。Compared with MMSE, more sensitive to mild dementia。

Time frame: Time Frame: the 1st day before the surgery；the 1st day after the surgery

Secondary Outcomes

Heart rate

Heart rate per minute

Time frame: Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）

Invasive arterial blood pressure

Invasive arterial puncture catheter, continuous arterial pressure monitoring

BIS

bispectral index

PETCO2

Partial pressure End-Tidal Carbon Dioxide

Cerebral oxygen saturation