To Study the Efficacy and Safety of L. Plantarum UALp-05TM in Diarrhea- Predominant-irritable Bowel Syndrome

Inclusion Criteria: 1. Males and females aged 18 to 70 years. 2. Participants with Irritable bowel syndrome (IBS) as per Rome IV IBS criteria: Recurrent abdominal pain on average at least 1 day/week in the last 3 months, associated with two or more of the following criteria: * Related to defecation (Maybe increased or decreased by defecation) * Associated with a change in the frequency of stool (increase in frequency) * Associated with a change in the form (appearance) of stool 3. History of abnormal bowel movements, which are predominantly diarrhea (more than one-fourth (25%) of bowel movements with BSS Types 6-7 and less than one-fourth (25%) with BSS Types 1-2) in the last one month prior to screening. 4. Average APS-NRS score of ≥ 6 for last 3 months prior to screening visit. 5. Fasting blood glucose levels ≤ 125 mg/dL (6.94 mmol/l). 6. Hemoglobin ≥ 10 g/dL. 7. Able to comply and perform the procedures requested by the protocol (consumption of study medications, filling scheduled eDiary for health updates, biological sample collection procedures and study visit schedule). 8. Participants with access to western toilet facilities. 9. Participants with non-vegetarian dietary preferences (Note: Non-vegetarian food will be defined as food derived from animals, birds, fish, shell-fish, etc) 10. Participants consuming non-vegetarian food for at least 2 times in a week. 11. SpO2 ≥ 96% as assessed by fingertip pulse oximetry 12. Participants who are sufficiently literate to understand the essence of the study, are informed about the purpose of the study, and understand their rights. 13. Participants who are able to give written informed consent and are willing to participate in the study. Exclusion Criteria: 1. Participants not meeting IBS-D diagnostic criteria (i.e. IBS-Constipation, Mixed or Unclassified). 2. Uncontrolled abnormal Thyroid Stimulating Hormone (TSH) value which is \< 0.35 or \> 4.94 μIU/mL. 3. Uncontrolled Type II DM (Controlled Type II diabetics can be included upon investigator's discretion). 4. Type I diabetes. 5. Uncontrolled hypertension defined as SBP ≥ 140 mm Hg and/or DBP ≥ 90 mm Hg. 6. Use of probiotics and/or prebiotics (In the form of supplements) within the last 4 weeks prior to screening. 7. Use of medicines (Prescription, OTC, etc), health supplements or herbal medicines expected to promote gut health and alleviate IBS related complications within the last four 4 months prior to screening. 8. Established diagnosis of Helicobacter pylori infection in last 3 months prior to screening. 9. History of surgical resection of the stomach, small intestine or large intestine. 10. Participants with acute gastroenteritis. 11. History or complications of inflammatory bowel disease (Crohn's disease or ulcerative colitis) or ischemic colitis. 12. Participants with complications from infectious enteritis. 13. History of any diet-based intolerance (gluten or lactose intolerance). 14. History of or complications from malignant tumors. 15. History of any significant neurological or psychiatric condition which may affect study participation or inference of study outcomes. 16. Consumption of psychotropic agents in the last 1 year prior to screening. 17. History (in past 2 years) of smoking or currently smoking or using any form of smokeless tobacco. 18. Participation in other clinical trials in last 90 days prior to screening. 19. Participants with heavy alcohol consumption, defined as: * For men: More than 14 standard alcoholic drinks (SAD)/week or more than 4 SAD in a day. * For women: More than 7 SAD/week or more than 3 SAD in a day. (NOTE - A standard alcoholic drink contains approximately 14 grams of alcohol, which is equivalent to 12 ounces of beer (\~5% alcohol), 8.5 ounces of malt liquor (\~9% alcohol), 5 ounces of wine (\~12% alcohol), 3.5 ounces of fortified wine (e.g., sherry or port), or 1.5 ounces of liquor (distilled spirits; \~40% alcohol). 20. Participants who have a clinically active state of systemic illness, which may include but is not limited to cardiovascular, endocrine, immune, respiratory, hepatobiliary, kidney and genitourinary, neuropsychiatric, and gastrointestinal system. To be ruled out by physician based on prior history and physical examination. 21. Females who are pregnant/planning to be pregnant/lactating or taking any oral contraceptives. 22. Any condition that could, in the opinion of the investigator, preclude the participant's ability to successfully and safely complete the study or that may confound study outcomes.