The purpose of this study is to determine the effects of respiratory muscle training (RMT) and nasal breathing on patients who have been infected with the SARS-CoV2 virus and continue to have lingering symptoms.
This study will be conducted virtually and will be completed at home using a cell phone application. Study participation involves the use of a RMT device, and/or nasal breathing. The purpose of this research is to evaluate the impact of RMT and nasal breathing on chronic symptoms of COVID-19 in patients that have recovered from SARS-CoV2. Subjects that have tested positive for the SARS-CoV2 infection and have completed a 14 to 30 day quarantine will be recruited.The RMT device will be used up to 2 times a day at a moderate intensity for 2 or 3 sets of 10 or 15 repetitions. Additionally, 2 sets of 10 nasal breathing techniques will be performed twice a day without the RMT device. Subjects will complete several surveys examining symptoms, physical activity, cognitive function, and quality of life at baseline, 2 weeks, and 4 weeks. Subjects will also perform phonation (speaking/speech sounds) and sit to stand tests at baseline, 2 weeks, and 4 weeks. All data will be collected through the use of a cell phone application. The cell phone application will also provide subjects with the proper RMT protocol. Additionally, subjects will receive coaching and instructions on how to use the breathing device, as well as instructions on how to complete the phonation and sit to stand test.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
2,268
2 sets of 10 breaths twice per day using the breather or 3 sets of 10 breaths, twice per day using the Breather Fit
2 sets of 10 breaths twice per day using the Breather or 3 sets of 10 breaths twice per day using the Breather Fit. Subjects will also be asked to complete 2 sets of 10 nasal breathing exercises either before or after the RMT exercise.
15 breaths twice per day using the Breather or 20 breaths twice per day using the Breather Fit
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Change in Phonation time
Speaking/ speech sounds
Time frame: change from baseline to 4 weeks
Change in Sit to stand executions
How many times an individual can go from sitting to standing in one minute
Time frame: change from baseline to 4 weeks
Change in number of reported COVID symptoms
question asking to report presence of COVID-related symptoms
Time frame: change from baseline to 4 weeks
Change in breathing difficulty
rating how difficult breathing is from 1 very difficult to 5 no difficulty at all
Time frame: change from baseline to 4 weeks
Change in reported affect of health on physical activity
rating of affect from 1 affects me severely to 5 not at all affected
Time frame: change from baseline to 4 weeks
Change in reported cognition
summary score of memory, alertness, sadness, anxiety and focus getting better (1), worse (-1) or no change (0) where higher score equals more improvement
Time frame: change from baseline to 4 weeks
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15 breaths twice per day using the Breather or 20 breaths twice per day using the Breather Fit at a lower intensity for a longer duration without break. Subjects will also perform 2 sets of 10 nasal breathing exercises either before or after the RMT exercise.
10 breaths, 3 times per week, at an intensity of 3 to 4 out of 10 using the Breather device.