To conduct a retrospective multicenter cohort study to define benchmark values for best achievable outcomes following transsphenoidal resection of pituitary adenomas.
Surgeons strive for the best possible outcome of their surgeries with the greatest possible chance for recovery of the patients. Therefore, monitoring and quality improvement is increasingly important in surgery. For this purpose, different concepts were developed with the aim to assess best achievable results for several surgical procedures and reduce unwarranted variation between different centers. The concept of a benchmark establishes reference values which represents the best possible outcome of high-volume centers and can be used for comparison and improvement. In the past years, the concept of benchmarking attaches greater importance in the field of healthcare, especially in surgery. Benchmark values are established within a patients' cohort for which the best possible outcome can be expected. To date, no valid concept exists to describe the outcome of patients after transsphenoidal resection of pituitary adenomas. The aim of our study is the establishment of robust and standardized outcome references after transsphenoidal surgery. After successful implantation of benchmarks from an international cohort of renowned centers, these data serve as reference values for the evaluation of novel surgical techniques and comparisons among centers or future clinical trials.
Study Type
OBSERVATIONAL
Enrollment
5,000
Transsphenoidal resection of pituitary adenoma
University Medical Center Hamburg-Eppendorf
Hamburg, Germany
RECRUITINGReoperation
Time frame: up to two weeks
CSF leak
Requiring intervention
Time frame: up to two weeks
Epistaxis
Requiring intervention
Time frame: up to two weeks
Meningitis
Time frame: up to two weeks
Diabetes insipidus
Time frame: up to two weeks
SIADH
Time frame: up to two weeks
Cerebral vasospasm
Time frame: up to two weeks
New hypopituitarism
Requiring hormone replacement
Time frame: up to two weeks
Normalization of hormone levels
Time frame: up to two weeks
New neurological deficit
Time frame: up to two weeks
Postoperative change of vision
Time frame: up to two weeks
Need for ICU care
Time frame: up to two weeks
Length of stay
Time frame: up to two weeks
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In-hospital mortality
Time frame: up to two weeks
Readmission to hospital
Related to transsphenoidal surgery
Time frame: At 6 months follow up
Electrolyte imbalance
Requiring drug treatment
Time frame: At 6 months follow up
New hypopituitarism
Requiring hormone replacement
Time frame: At 6 months follow up
New neurological deficit
Time frame: At 6 months follow up
CSF leak
Requiring intervention
Time frame: At 6 months follow up
Termination of hypersecretion
If applicable
Time frame: At 6 months follow up
MRI resection control
If applicable
Time frame: At 6 months follow up