The Effect of Thyroid Antibodies on Female Reproductive Function and Pregnancy Outcomes

N/AUnknownNCT04952012

Second Affiliated Hospital, School of Medicine, Zhejiang University4,000 enrolled

Overview

Some women at reproductive age have positive antithyroid antibodies (ATAs). Thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) are the most common ATAs. This study aimed to evaluate the impact of ATAs on maturation of women reproductive system and pregnancy outcomes.

Study Type

OBSERVATIONAL

Enrollment

4,000

Conditions

Thyroiditis, Autoimmune

Interventions

LT4DRUG

LT4 is used to improve the thyroid function of pregnant women.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age during 18-45y; * Women tested for TPOAb and/or TgAb, TSH, free T3, free T4, total T3 and total T4 during the 1st trimester of pregnancy Exclusion Criteria: * Multiple pregnancies; * Age \< 18 y or \> 40 y; * L-T4 or PTU intervention before pregnancy; * Other autoimmune diseases.

Locations (1)

Second Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

RECRUITING

Outcomes

Primary Outcomes

Incidence rate of pregnancy complications in women with or without thyroid antibodies

Time frame: 1 year

Central Contacts

Min Jin

CONTACT

057187783759 min_jin@zju.edu.cn

Data from ClinicalTrials.gov

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