This cohort study is a large population-based study in the UK to determine the risks of comorbid mental health conditions (including depression, anxiety and other potential psychological complications of vitiligo) in adults with vitiligo compared to controls and to evaluate whether the relative risks may vary by different ethnicity.
This study has two primary outcomes 1) Prevalence and incidence of mental health condtions in people diagnosed with vitiligo compared to matched controls and 2) Primary care and secondary healthcare utilisation in patients diagnosed with vitiligo and having a prevalent depressive conditon compared to matched controls. In addition, the study examines risk of time off work and unemployment in people diagnosed with vitiligo compared to matched controls.
Study Type
OBSERVATIONAL
Enrollment
36,104
Common mental health conditions consist of depressive episodes, recurrent depressive disorder and anxiety disorder.
Momentum Data Ltd
London, United Kingdom
Number of Participants With Depressive Episodes
Prevalence of common mental health conditions (depressive episodes) in adult people diagnosed with vitiligo and matched controls without vitiligo.
Time frame: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.
Risk of Depressive Episodes Within Adult Patients With Vitiligo
Adjusted hazard ratio calculated using Cox proportional hazards models
Time frame: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.
Number of Participants With Anxiety Disorder
Prevalence of common mental health conditions (Anxiety Disorder) in adult people diagnosed with vitiligo and matched controls without vitiligo.
Time frame: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.
Number of Participants With Recurrent Depressive Disorder
Prevalence of common mental health conditions (Recurrent Depressive Disorder) in adult people diagnosed with vitiligo and matched controls without vitiligo.
Time frame: At the time of diagnosis in all people diagnosed with vitiligo 2004-2020 inclusive. For matched controls, the date of diagnosis of their matched case.
Risk of Anxiety Disorder Within Adult Patients With Vitiligo
Adjusted hazard ratio calclulated using Cox Proportional hazard models
Time frame: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.
Risk of Recurrent Depressive Disorder Within Adult Patients With Vitilgo
Adjusted hazard ratio calculated using Cox proportional hazards models. Adjusted for age, gender, ethnicity, social deprivation quintile, body mass index, smoking status, alcohol use and comorbidities (hypertension, hyperlipidaemia, type 2 diabetes, atrial fibrillation, angina, myocardial infarction, heart failure, stroke, chronic kidney disease stages 3-5, chronic obstructive pulmonary disease, asthma, chronic liver disease and dementia).
Time frame: Within two years of vitiligo diagnosis. For matched controls, within two years of the date of diagnosis of their matched case.
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