The purpose of this study is to determine the effects of the clinical course of treatment as well as long-term symptoms of COVID-19 on respiratory function, exercise capacity, and quality of life.
This study will be completed over 4 sessions at the Mayo Clinic at either the Scottsdale Arizona or Rochester Minnesota locations. You will be asked to complete a series of questionnaires, lung function tests, and exercise tests at two time points: ≥ 28 days post diagnosis and 4-6 months after the first laboratory visit. All visits will take approximately 2 hours. During visits 1 and 3 a series of questionnaires as well as breathing tests, and an exercise test will be completed on a stationary bike. You will also be asked to breathe a gas mixture out of a bag to obtain measures of gas movement and sensitivity. During visits 2 and 4 you will complete an exercise test on a stationary bike to measure changes from the previous exercise test and a chest scan.
Study Type
OBSERVATIONAL
Enrollment
80
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Change in diffusion capacity of the lungs
change in diffusing capacity of the lungs for carbon monoxide and its components
Time frame: through study completion, an average of 5 months
Change in airway morphology
CT assessment of airway diameter and thickness
Time frame: through study completion, an average of 5 months
change basic spirometry
Measurement of basic lung function using forced vital capacity (FVC), slow vital capacity (SVC), forced expiratory volume at one second (FEV1), maximal inspiratory pressure (MIPS), maximal expiratory pressure (MEPS), exhaled nitric oxide (ExNO), forced oscillation technique (FOT), overnight pulse oximetry
Time frame: through study completion, an average of 5 months
Change in peak aerobic capacity
Change in examine post exertional malaise
Time frame: through study completion, an average of 5 months
Presence of post-exertional malaise
Evaluation of change in performance on maximal exercise test over two days to identify presence of post-exertional malaise
Time frame: through study completion, an average of 5 months
Change in symptoms
St. George's respiratory Questionnaire scoring of pulmonary symptoms. Scores range from 0 to 100, with higher scores indicating more limitations.
Time frame: through study completion, an average of 5 months
change in quality of life
SF-36 questionnaire assessment of physical and mental health. Two scores one for physical functioning and one for mental functioning. Scores range from 0-100 with a higher score indicating better health
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: through study completion, an average of 5 months