Epilepsy with centrotemporal spikes (ECTS) is the most common epilepsy syndrome in children. Language impairment has been widely investigated in patients with ECTS, but little is known about the cognitive dysfunction of processing speed and its neuroimaging mechanism.
OBJECTIVE To investigate the processing speed dysfunction in patients with ECTS, and the associated brain functional abnormality using functional magnetic resonance imaging (fMRI) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). DESIGN, SETTING, AND PARTICIPANTS This study prospectively enrolled ECTS patients (n = 28) from June 2019 and June 2021. Twenty age- and gender- matched healthy children and another twenty children with extracranial tumors were enrolled as controls. Patients with ECTS and healthy controls underwent neuropsychological testing and fMRI examination. In addition, ECTS patients and children with extracranial tumors underwent 18F-FDG PET examination.
Study Type
OBSERVATIONAL
Enrollment
68
Department of Nuclear Medicine and PET/CT Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
Processing speed index
Processing speed index was measured according to Wechsler Intelligence Scale for Children
Time frame: Through study completion, about 2 years
Standardized uptake value ratio
Standardized uptake value ratio was measured from 18F-FDG PET for brain glucose metabolism
Time frame: Through study completion, about 2 years
Functional connectivity
Functional connectivity was measured from fMRI for brain regional interactions
Time frame: Through study completion, about 2 years
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