Screening of Specific Genes for Pigmented Villous Nodular Synovitis

Peking University Third Hospital60 enrolled

Overview

This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions. Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

This study retrospectively analyzed the symptoms, time of onset, injury history, laboratory examinations, imaging examinations, and intraoperative conditions of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions (VAS score, SF-36 score). Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pigmented Villonodular Synovitis

Interventions

Arthroscopic synovectomyPROCEDURE

Arthroscopic synovectomy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Clinical diagnosis of pigmented villonodular synovitis. 2. Clinical diagnosis of giant cell tumor of tendon sheath Exclusion Criteria: 1. No surgical treatment. 2. There were no pathological specimens during the operation. 3. The age of the patient is less than 18 years old or more than 60 years old. 4. The operation record shows nodular type.

Locations (1)

Institute of Sports Medicine, Peking University Third Hospital, Beijing Key Laboratory of Sports Injuries， Beijing, China

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

Difference of scale score between immunohistochemistry positive group and negative group

Difference of Visual Analog Score for pain between CSF-1 immunohistochemistry positive group and negative group