Probiotic and Antibiotic Therapies in Women With Unexplained Infertility

Inclusion Criteria: 1. Female aged 18-40 at the time of egg retrieval 2. Generally in good health (at physician's discretion) 3. Diagnosed with Unexplained Infertility 4. Diagnosed with or suspected of having endometriosis (at ONE Fertility physician's discretion) 5. Normal uterine cavity as assessed by prior sonohysterogram 6. Planning to undergo Frozen Embryo Transfer with ≥1 frozen blastocyst ≥3BB (grade Gardner) to transfer 7. Able to understand, comply and consent to protocol requirements and instructions 8. Able to attend scheduled study visits and complete required investigations Exclusion Criteria: 1. Any known endometrial pathologies other than endometriosis 2. Polycystic ovary syndrome 3. Ovulatory dysfunction 4. Male factor infertility (Total Motile Sperm Count \<5M/mL) 5. Poorly controlled auto-immune disease and/or diabetes (at physician's discretion) 6. Is immune-compromised 7. Cockayne syndrome 8. Allergy to Metronidazole 9. Allergy to rice (bran and hull), pomegranate, Acacia gum, hypromellose, fermented gellan gum, chlorophyllin, or sunflower oil 10. Known intolerance of Lactobacillus and/or Bifidobacterium-containing probiotics 11. Antibiotic use in the past month 12. Use of any of the following: 1. Oral probiotics 2. Alcohol 3. Anticoagulant therapies (Warfarin type) 4. Drugs containing alcohol 5. Busulfan 6. Cyclosporin 7. Disulfiram 8. 5-Fluoruracil 9. Lithium 10. Phenytoin or Phenobarbital 11. Vecuronium 12. Proton pump inhibitors 13. Histamine H2-receptor antagonists 13. Currently experiencing nausea, fever, vomiting, bloody diarrhea or severe abdominal pain