The purpose of this study is to describe type and extent of psychological distress (adverse effects) in patients undergoing surgery for colorectal cancer with peritoneal metastases and after surgery for colorectal cancer with involvement of the urinary bladder.
After being informed about the study all patients giving written informed consent will be distributed a questionnaire asking questions on depression, anxiety, self-reported cognitive issues, sleep issues, quality of life and 'fear of cancer recurrence'. All these aspects will be investigated using validated questionnaires. Once the investigators have the preliminary results (type and extent of psychological distress developed after CRS+HIPEC or PE) the investigators plan to conduct a workshop. In this workshop experts in different areas regarding psychological distress, project leaders, professor from the 'National Center of Late Adverse Effects after Cancer in Pelvic Organs' (Denmark) and patients will participate. With the input of experts and patients, a treatment strategy will be developed, and also an assessment will be made concerning which patients are likely to benefit from treatment by these experts, and which patients could potentially benefit from counselling by their general practitioner or via self-helping tools at home. The investigators plan to conduct this workshop autumn 2021 and start counselling spring 2022.
Study Type
OBSERVATIONAL
Enrollment
225
Department of Surgery, Aarhus University Hospital
Aarhus, Denmark
RECRUITINGDepartment of Surgery, Karolinska University Hospital
Solna, Stockholm County, Sweden
NOT_YET_RECRUITINGDepartment of Surgery, Skånes University Hospital, Malmö
Malmo, Sweden
NOT_YET_RECRUITINGDevelopment of depression after PE or CRS+HIPEC for colorectal cancer
Descriptive analysis will be done using the following questionnaire: PHQ-9 (patient health questionnaire)
Time frame: PE cohort: Development and change in adverse effects 3, 6 and 12 months after surgery. HIPEC cohort: Development and change in adverse effects 3, 6, 12, 18, 24, 36, 48 and 60 months after surgery
Development of anxiety after PE or CRS+HIPEC for colorectal cancer
Descriptive analysis will be done using the following questionnaire: GAD-7 (general anxiety disorder)
Time frame: PE cohort: Development and change in adverse effects 3, 6 and 12 months after surgery. HIPEC cohort: Development and change in adverse effects 3, 6, 12, 18, 24, 36, 48 and 60 months after surgery
Development of cognitive dysfunction after PE or CRS+HIPEC for colorectal cancer
Descriptive analysis will be done using following the questionnaire: Items regarding cognitive functioning from the EORTC item library
Time frame: PE cohort: Development and change in adverse effects 3, 6 and 12 months after surgery. HIPEC cohort: Development and change in adverse effects 3, 6, 12, 18, 24, 36, 48 and 60 months after surgery
Development of sleeping issues after PE or CRS+HIPEC for colorectal cancer
Descriptive analysis will be done using following the questionnaire: ISI (insomnia sleep index)
Time frame: PE cohort: Development and change in adverse effects 3, 6 and 12 months after surgery. HIPEC cohort: Development and change in adverse effects 3, 6, 12, 18, 24, 36, 48 and 60 months after surgery
Development of fatigue after PE or CRS+HIPEC for colorectal cancer
Descriptive analysis will be done using following the questionnaire: FACIT V4 (fatigue scale)
Time frame: PE cohort: Development and change in adverse effects 3, 6 and 12 months after surgery. HIPEC cohort: Development and change in adverse effects 3, 6, 12, 18, 24, 36, 48 and 60 months after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Development of ´fear of cancer recurrence' after PE or CRS+HIPEC for colorectal cancer
Descriptive analysis will be done using following the questionnaire: Fear of cancer recurrence - SF
Time frame: PE cohort: Development and change in adverse effects 3, 6 and 12 months after surgery. HIPEC cohort: Development and change in adverse effects 3, 6, 12, 18, 24, 36, 48 and 60 months after surgery
Risk factors associated with developing psychological distress
Univariate and multivariate regression analysis will be performed to identify potential risk
Time frame: PE cohort: Development and change in adverse effects 3, 6 and 12 months after surgery. HIPEC cohort: Development and change in adverse effects 3, 6, 12, 18, 24, 36, 48 and 60 months after surgery.