This study aims to investigate long term outcomes of surgical intervention for Hirschsprung's disease and to explore the relation between scintigraphic defecography, type of surgery performed and symptoms as evaluated by a disease specific questionnaire.
Hirschsprung's disease (HD) is a congenital deficiency with incomplete development of nerves in the gastrointestinal tract leading to absence of peristalsis in the affected segment of bowel. Most patients require surgical intervention with removal of the affected segment of bowel. Physical symptoms affecting quality of life are not uncommon in patients born with HD in spite of surgical intervention. This renders a need for a tool for evaluating the functional outcome in these patients. Scintigraphic defecography examines the defecation in terms of the ability to empty the bowel and examines the relocation of faeces within the bowel in relation to defecation. This study aims to explore the relation between scintigraphic defecography, type of surgery performed and symptoms as evaluated by a disease specific questionnaire (Hirschsprung and Anorectal Malformations Quality of Life Questionnaire).
Study Type
OBSERVATIONAL
Enrollment
32
Odense University Hospital
Odense, Region Syddanmark, Denmark
Evacuation fraction (%) of radioactive material between first, second and third round of scintigraphic imaging
The fraction of evacuated radioactive material by defecation between rounds of scintigraphic imaging
Time frame: Day 1
Presence of retrograde movement of radioactive material (yes/no)
Presence of retrograde movement of radioactive material within the bowel on scintigraphic images between rounds of scintigraphic imaging
Time frame: Day 1
Hirschsprung and Anorectal Malformations Quality of life Questionnaire sub scales and total score
Disease specific questionnaire including sub scales for laxative and constipating diet, presence of diarrhoea and constipation, faecal and urinary incontinence, social and emotional functioning, body image, physical symptoms and sexual functioning. Each item is phrased as a multiple-choice question with four response options; never, once in a while, often and very often. Responses are linearly transformed on a 0-100 scale with a higher score indicating better QOL.
Time frame: Day 1
Type of surgical intervention performed in each individual (for example pull-through surgery)
Type of surgical intervention performed to treat Hirschsprung's disease
Time frame: Day 1
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.