Microbial Markers for AGI

Peking University Third Hospital584 enrolled

Overview

AGI is very common in ICU and sometimes will trigger the development of gut derived sepsis. Thus, to find out the biomarker in early stage is very important to improve the overall prognosis of critically ill patients. In this project we try to find out the microbial biomarker of AGI through multi-omic technology.

Study Type

OBSERVATIONAL

Enrollment

584

Conditions

Acute Gastrointestinal Injury

Interventions

none interventionOTHER

none intervention.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: All those critically ill patients with anticipated ICU stay for more than 2 days Exclusion Criteria:Patients will be excluded if they have any of the following situations: patients who have not signed the informed consent; Unable to tolerate intra-abdominal pressure monitoring; pregnant woman; Patients after bladder surgery; Systemic diseases and recent use of related drugs; He had a history of infectious diseases, such as tuberculosis or PPD positive. History of hypertension and poor blood pressure control (SBP / DBP \> = 140mmHg); Patients with severe mental illness; Long term use of traditional Chinese medicine, probiotics, gastric mucosal protective agents, proton pump inhibitors, chemotherapy or immunosuppressive drugs, etc. were not included if the drug was not stopped within one month before admission. \-

Locations (1)

Peking University Third Hospital

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

The AUC value of the combined markers

The combined diagnostic accuracy of AGI through omic parameters

Time frame: 1 year

Data from ClinicalTrials.gov

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