Night Time Walking to Improve Glycaemic Control in Healthy Adults

Monash University

Overview

Randomised crossover trial to compare early vs late walking on postprandial glycaemic response at night time.

In this crossover trial, eligible participants will be randomised to a 30-minute bout of physical activity (30 minute walk) either during the day or after an evening meal. The postprandial response to the evening meal will be analysed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Conditions

Postprandial Hyperglycemia Insulin Resistance

Interventions

Early exerciseOTHER

Participants will exercise for 30 minutes prior to an evening meal.

Late exerciseOTHER

Participants will exercise for 30 minutes after an evening meal.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria * Men and Women aged 18 to 65 years of age * Waist circumference of \<94cm and \<80cm for Caucasian males and females, respectively * Waist circumference of \<90cm and \<80 cm for Asian males and females, respectively * Willingness to provide written informed consent and willingness to participate and comply with the study Exclusion criteria * Current or recent treatment (within 6 months) with medications that influence blood glucose * Fasting blood glucose ≥ 7 mmol/L * Individuals diagnosed with type 1 or type 2 diabetes mellitus, chronic gastrointestinal disorders (including inflammatory bowel disease and celiac) or any other condition deemed unstable * Serious health conditions that may affect participation e.g. liver or thyroid dysfunction, recent major surgery * Not able to walk for 30 mins at 5-5.5 km/hr * Women planning pregnancy, pregnant or lactating.

Outcomes

Primary Outcomes

Postprandial glucose

Change in glucose incremental area under the curve (iAUC) in response to a meal challenge

Time frame: Three hour glucose iAUC will be calculated at nine time points (0, 15, 30, 45, 60, 90, 120, 150 and 180 mins) after beginning consumption of the test meal.

Secondary Outcomes

Postprandial insulin

Change in insulin incremental area under the curve (iAUC) in response to a meal challenge

Time frame: Three hour insulin iAUC will be calculated at six time points (0, 30, 60, 90, 120 and 180 mins) after beginning consumption of the test meal.

Data from ClinicalTrials.gov

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