Cardiac surgery is a complex operative procedure with a substantial risk of postoperative complications, so that patients undergoing valve surgery are usually transferred to the intensive care unit postoperatively. Various substances are used to maintain the required sedation, such as volatile anaesthetics and intravenous sedatives combined with analgetic therapy using opioids. The study intends to investigate to what extent the already well-described effect of volatile anaesthetics on recovery can be realised despite the need for differentiated intensive care and medical management.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Enrollment
100
Patients admitted after valve surgery are receiving intensive care using volatile sedative per anaesthetic conserving device. The subject of the study is medical and nursing time management..
University Hospital Frankfurt
Frankfurt am Main, Hesse, Germany
Time to extubation
Time from admission on ICU until awakening and Extubation.
Time frame: through study completion, an average of 2 days
Time to neurocognitive assessability
Time from admission on ICU until awake and neurocognitive assessable.
Time frame: through study completion, an average of 2 days
Required setup time of the intensive care workplace
Required setup time of the intensive care workplace to provide volatile or intravenous sedation.
Time frame: through study completion, up to 24 hours
Factor related to the course of intensive care: blood loss
Measured Postoperative Blood Loss
Time frame: through study completion, an average of 24 hours
Factor related to the course of intensive care: kidney injury
Measured increases in serum renal retention levels: creatinine and urea in terms of renal failure according to Kidney Disease - Improving Global Outcomes (KDIGO) criteria.
Time frame: through study completion, an average of 24 hours
Factor related to the course of intensive care: acid-base balance
Measured serum lactate levels and hypercapnia
Time frame: through study completion, an average of 24 hours
Factor related to the course of intensive care: lung function parameters
Required inspiratory oxygen fraction
Time frame: through study completion, an average of 24 hours
Factor related to the course of intensive care:cardiovascular medication
Required dosage of adrenaline, noradrenaline, vasopressin or milrinone
Time frame: through study completion, an average of 24 hours
Factors related to the course of operative procedure
time of the intraoperative procedure including the heart-lung-machine
Time frame: through study completion, up to 24 hours
Intra-hospital mortality
Intra-hospital mortality - Safety outcome
Time frame: through study completion, an average of 7 days
Liver failure
Intra-hospital liver failure - Safety outcome
Time frame: through study completion, an average of 7 days
postoperative nausea and vomiting
Detection of postoperative nausea and vomiting
Time frame: through study completion, up to 24 hours
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