To investigate the hemodynamic effects of PACAP38 after glibenclamide administration.
22 healthy participants will randomly be allocated to receive PACAP38 infusion followed by glibenclamide or placebo on two different days. The aim of the study is to investigate the vascular effect of PACAP38 after glibenclamide administration. Repeated measurements covering the arteria radialis (RA), superficial temporal artery (STA) and middle cerebral artery (MCA) before and after PACAP38 infusion and glibenclamide/placebo administration
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
22
Oral administration of glibenclamide/placebo. To investigate the role of PACAP38 on cranial arteries in healthy volunteers after glibenclamide/placebo administration .
PACAP38 infusion
Danish Headache Center
Copenhagen, Capital Region, Denmark
Headache
Headache intensity will be recorded by numerical rating scale (NRS) from 0 to 10 (0, no headache; 1, a feeling of pressure; 10, worst imaginable headache).
Time frame: Time of headache measurements is from before (-20 minutes) and up to 12 hours after PACAP38 infusion
Changes in the arterial radialis (RA), superficial temporal artery (STA) and middle cerebral artery (MCA).
Repeated measurements covering the diameter of RA, STA and MCA before and after PACAP38 infusion and glibenclamide/placebo administration measured by centimeter (cm)
Time frame: Time of measurements is baseline and repeatedly every 20 minutes for 260 minutes.
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