Pre-operative Neoadjuvant Therapy Combined With Surgery for Treating Stage III Hepatocellular Carcinoma

Inclusion Criteria: * Age 18-80 years old, both gender * Confirmed diagnosis of stage III hepatocellular carcinoma(HCC) * Fulfill the criteria of surgery * No other severe comorbidity * Eastern Cooperative Oncology Group score(ECOG) 0-2 * Expected survival \> 3months * Informed consent obtained. Exclusion Criteria: * Received chemoradiotherapy or other antineoplastic drugs * Severe cirrhosis with Child-Pugh score \>10 * Total bilirubin \> 1.5 times upper limit, AST or ALT \> 2times upper limit, indocyanine green retention rate after 15 min(ICG15) \>=40%; * Not fulfill the surgery criteria * Received major surgery within 1month * History of other tumor * Participate other clinical trial within 1month * Drug or alcohol abuse, AIDS * Uncontrollable epileptic seizure or cognitive disorder * Severe allergy * Other unsuitable conditions.