Sertraline Combined With Fluvoxamine in the Treatment of Refractory Obsessive-compulsive Disorder

Second Affiliated Hospital, Zhejiang University, School of Medicine400 enrolled

Overview

To verify that sertraline combined with fluvoxamine is superior to sertraline combined with aripiprazole

To verify that sertraline combined with fluvoxamine is superior to sertraline combined with aripiprazole, and to observe the indicators of improving patients' cognitive function and adverse drug reactions, so as to provide evidence-based evidence for supplementing the treatment guidelines for obsessive-compulsive disorder

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

400

Conditions

OCD

Interventions

sertraline fluvoxamineDRUG

the initial dose of sertraline was given 50mg/d and the initial dose of fluvoxamine was 50mg/d, and the target dose of sertraline was gradually increased to 200mg/ d and the target dose of fluvoxamine was 200-300mg/d within 2 weeks, and the specific dose adjustment process was determined by the doctors on the basis of patients' conditions

sertralineDRUG

The initial dose of sertraline was 50mg/d and the initial dose of aripiprazole was 5mg/d. The target dose of sertraline was 200mg/ d and the target dose of aripiprazole was 5-20mg/d within 2 weeks, and the specific dose adjustment process was determined by the doctors on the basis of patients' conditions

Eligibility

Sex: ALLMin age: 12 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The Diagnostic criteria of OCD in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-V), as well as the definition of refractory OCD, are as follows: failure to respond to oral treatment with at least two effective doses of antidepressants, including: Fluoxetine (≥20mg/ d), fluvoxamine (≥200mg/d), sertraline (≥150mg/d), and paroxetine (≥ 40mg/d) were all treated for at least 12 weeks. The Yale-Brown compulsive scale (Y-BOCS) score decreased by \< 35%. * The total score of Yale- Brown compulsion scale (Y-BOCS) ≥16 points. (3)age 12 \~ 45 years. Exclusion Criteria: * Exclusion of severe organic brain disease; * Severe physical illness; * Other mental disorders such as tics, disruptive disorders, eating disorders and autism spectrum disorders; * Pediatric streptococcal infection causedby autoimmune neuropsychiatric disease (PANDAS); * Alcohol and drug dependence; Angle-closure glaucoma; * Suicidal tendencies; * Previous history of drug allergies related to research; * Pregnant and lactating women.

Locations (1)

The Fourth Affiliated Hospital of Zhejiang University Medical College

Yiwu, Zhejiang, China

RECRUITING

Outcomes

Primary Outcomes

Y-BOCS score

Treatment effectiveness was defined as a reduction of ≥35% in Y-BOCS score compared to baseline(12 weeks). Treatment recovery: Y-BOCS score below 8 (12 weeks)

Time frame: 12 weeks

Ratio of Y-BOCS score reduction from baseline

Treatment effectiveness was defined as a reduction of ≥35% in Y-BOCS score compared to baseline(12 weeks).

Time frame: 12 weeks

Central Contacts

Zheng Lin, Doctor

CONTACT

13757118261 linzzr@126.com

Data from ClinicalTrials.gov

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