Pulmonary Diffusing Capacity During Postural Postural Changes and Acute Exercise

Rigshospitalet, Denmark20 enrolled

Overview

The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) has recently been standardised and validated for clinical use. It involves a very short breath-hold time (≤5 seconds), and it may be repeated up to 12 times without affecting measurements, and it is thus ideal for assessing acute changes in pulmonary diffusing capacity and its components during various physiological manoeuvres. The aim of the present study is to compare the test-retest reliability of pulmonary diffusing capacity measurements during postural changes (sitting vs. supine) vs. rest-to-exercise. DLCO/NO will either be measured in the sitting position during rest vs. exercise or in the sitting and supine posture, and this will be repeated within 1-7 days in 20 healthy individuals that will be randomised to one of the two interventions. Statistically,the test-retest relaibility of sitting-to-supine vs. rest-to-exercise changes in DLCO/NO will be compared by parametric methods.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Clinical Assessments of Pulmonary Diffusing Capacity

Interventions

Rest-to-exerciseDIAGNOSTIC_TEST

Pulmonary diffusing capacity is assessed at rest and during exercise (70% of VO2max on a bicycle ergometer)

Sitting-to-supineDIAGNOSTIC_TEST

Pulmonary diffusing capacity is assessed in the sitting and supine position

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: • Regular exercise (1-3 timer per week) Exclusion Criteria: * Any known medical condition that requires regular medication or any known lung condition * Smoking * Symptoms of disease within 2 weeks prior to the study * Abnormal lung function test * Pregnancy

Locations (1)

Rigshospitalet

Copenhagen, Denmark

Outcomes

Primary Outcomes

Between intervention DLNO/DLCO-ratio repeatability coefficient

Test-retest reliability coefficient of rest-to-exercise and supine-to-prone DLNO/DLCO-ratio

Time frame: 1 week

Between intervention DLCO repeatability coefficient

Test-retest repeatability coefficient of rest-to-exercise and supine-to-prone DLCO

Time frame: 1 week

Between intervention DLNO repeatability coefficient

Test-retest repeatability coefficient of rest-to-exercise and supine-to-prone DLNO

Time frame: 1 week

Secondary Outcomes

Between intervention DM repeatability coefficient

Test-retest repeatability coefficient of rest-to-exercise and supine-to-prone DM

Time frame: 1 week

Between intervention Vc repeatability coefficient

Test-retest repeatability coefficient of rest-to-exercise and supine-to-prone Vc

Time frame: 1 week

Data from ClinicalTrials.gov

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