Clinical Phenotypes of COPD Patients Between in Plateau and Plain

Peking University Third Hospital104 enrolled

Overview

We aimed to collect clinical and radiological data of patients with stable COPD in plateau and plain, and compare the clinical phenotypic characteristics and imaging features of COPD patients in these two areas.

The purpose of this study was to investigate the clinical phenotypic characteristics and imaging features of patients with stable chronic obstructive pulmonary disease (COPD) in plateau and plain. We conducted a cross-sectional study, collecting clinical data of stable patients in plateau and plain, and comparing the clinical phenotypic characteristics and imaging features of COPD patients in these two areas.

Study Type

OBSERVATIONAL

Enrollment

104

Conditions

Pulmonary Disease, Chronic Obstructive

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * meeting the diagnosis of COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines and had definite airflow limitation with a post-bronchodilator forced expiratory volume in 1 second (FEV1) / forced vital capacity (FVC)\<0.7. Exclusion Criteria: * age \<40 years; * subjects with airway diseases other than COPD; * acute exacerbation of COPD in the past 3 months; * active tuberculosis; * cardiovascular or cerebrovascular events in the past 3 months; * cognitive dysfunction such as vascular dementia or Alzheimer's disease; * refusal to participate in this study.

Locations (1)

Peking University Third Hospital

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

Assessment of respiratory symptoms

COPD Assessment Test

Time frame: Data were obtained during the interview.

Exacerbation

Frequency of exacerbations in the past year

Time frame: Data were obtained during the interview.

Spirometry testing

FEV1 %predicted, FVC %predicted, ratio of FEV1/FVC

Time frame: Data were obtained during the interview.

Emphysema

The percentage of the LAA divided by total lung volumes (LAA%) was used as an index of the severity of emphysema in quantitative CT examination.

Time frame: Within 3 months of the interview.

Airway remodeling -1

Bronchial wall thickness (WT, mm) was used as one of the measurements for assessment of airway remodeling in quantitative CT examination.

Time frame: Within 3 months of the interview.

Airway remodeling -2

Luminal area (LA, mm2) was used as one of the measurements for assessment of airway remodeling in quantitative CT examination.

Time frame: Within 3 months of the interview.

Airway remodeling -3

Bronchial wall area (WA, mm2) was used as one of the measurements for assessment of airway remodeling in quantitative CT examination.

Time frame: Within 3 months of the interview.

Data from ClinicalTrials.gov

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