Investigator seeks to determine wether integrating an addiction team into a liver transplantation unit improves the prognosis of patients with alcohol-related liver disease requiring liver transplantation. Our hypothesis is that patients managed by an addiction team before and after liver transplantation have less frequent alcohol relapses, thus decreasing the risk of cardiovascular complications, de novo cancer, recurrence of alcohol-related cirrhosis, and consequently increasing their overall survival.
In this observational, retrospective and multicentre study, investigator seek to determine the effect of integrating an addiction team into liver transplantation unit on prognosis of patients with alcohol-related liver disease requiring liver transplantation. Investigatore plan to compare patients in 2 groups, depending on whether they have received or not specific addiction care before and after transplantation. This study was conducted over a period of 15 years in three French liver transplant units.
Study Type
OBSERVATIONAL
Enrollment
616
Liver transplantation
Uhmontpellier
Montpellier, France
Overall survival of patients transplanted for alcoholic liver disease.
Patient time (delay between date of transplantation and date of last news) + state (alive or deceased)
Time frame: Date of last news (at least 5 years for surviving patients)
Alcohol relapse rate
Number of patients with alcohol relapse among all transplanted patients.
Time frame: Date of last news (at least 5 years for surviving)
Severe alcohol relapse rate
Number of patients with severe alcohol relapse among all transplanted patients
Time frame: Date of last news (at least 5 years for surviving)
Rate of alcohol-related cirrhosis recurrence
Number of patients with alcohol-related cirrhosis among all transplanted patients.
Time frame: Date of last news (at least 5 years for surviving)
Rate of development of cardiovascular risk factors
Number of patients developing one or more cardiovascular risk factors (hypertension, dyslipidemia, diabetes, smoking) among all transplanted patients.
Time frame: Date of last news (at least 5 years for surviving)
Cardiovascular event rate
Number of patients with one or more cardiovascular events (coronary syndrome, stroke, arterial disease) among all transplant patients.
Time frame: Date of last news (at least 5 years for surviving)
De novo cancer-free survival
Number of patients developing de novo cancer as a function of time among all transplanted patients
Time frame: Date of last news (at least 5 years for surviving)
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