Early Detection of Hepatocellular Carcinoma in a High-risk Prospective Cohort (ELEGANCE)

Inclusion Criteria: * Male and female patients, 50 to 90 years of age at the time of signing the informed consent form, except for patients recruited under the cirrhotic group, patients of 40 to 90 years of age can be included. * Patient has serum alpha-fetoprotein (AFP) within normal range of the investigating laboratory in the past 3 months. For patients with AFP level out of the normal range of the investigating laboratory and up to 15.0ug/L, patient will be eligible if patient has a CT/MRI scan that exclude HCC in the past 3 months. * Patient has ultrasound hepatobiliary system (US HBS) that does not show lesion suspicious for HCC or, CT / MRI scan that exclude HCC, in the past 3 months * Patient is estimated to survive more than 3 years * Patient with any of the following chronic liver disease: 1. liver cirrhosis of any etiology, identified by elastography (liver stiffness \> 13 kPa), US, CT, MRI or liver biopsy, Child-Pugh class A and B 2. non-cirrhotic chronic viral hepatitis (B or C) or both 3. non-alcoholic fatty liver disease (NAFLD) 4. non-alcoholic steatohepatitis (NASH) * Patient is able to comply with scheduled visits, assessments and other study procedures * Patient is willing to provide informed consent before enrolment in the study Exclusion Criteria: * Patient with confirmed diagnosis of HCC by the American Association for the Study of the Liver Disease (AASLD) imaging criteria or histology / cytology within the last 5 years * Patient with Child-Pugh C cirrhosis at time of enrolment (based on the judgement of the Investigator) * Patient with active hepatic encephalopathy at time of enrolment * Patient is known to be positive for the Human Immunodeficiency Virus (HIV) * Patient has psychiatric or addictive disorders that may compromise his/her ability to give informed consent, or to comply with the study procedures * Patient is unable to provide informed consent or refuse blood taking * Patient has any other condition which, in the opinion of the Investigators, would make the patient unsuitable for enrolment or could interfere with completion of the study