Generalized epilepsy is rarely reported in patients with Wilson disease (WD) and lacks experience in clinical practice. We aim to provide better experience for the diagnosis and treatment for WD patients with epilepsy in the future.
A retrospective study was performed in 13 Chinese WD patients with generalized epilepsy. Each patient was diagnosed with WD by clinical evaluation and genetic screening. Patients were given small doses of antiepileptic drugs (AEDs), followed by copper-chelation therapy when the seizures stabilized. Clinical manifestations, brain imaging changes, and treatment and outcome after a long-term follow-up were analyzed.
Study Type
OBSERVATIONAL
Enrollment
13
Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA)
Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Number of participants with treatment stop seizures attacks
After standard treatment, the patients would stop attacks and get improved.
Time frame: 12 month
Number of participants with treatment have improved brain MRI
After standard treatment, the abnormalities of brain MRI would get better in patients.
Time frame: 12 month
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