The purpose of this study is to explore the microflora characteristics of different ecological loci and multiple metabolic pathways in Crohn's disease patients with different disease course states.
This study aims to investigate the characteristics of microflora in the oral and tongue base, small intestinal stomy and lower respiratory tract, as well as the characteristics of multiple metabolic pathways such as bile acid metabolism and amino acid metabolism in Crohn's disease patients with different course states.
Study Type
OBSERVATIONAL
Enrollment
60
Shanghai 10th People's Hospital
Shanghai, Shanghai Municipality, China
Oral microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls
The results were based on the 16S rRNA sequencing
Time frame: 3 months
Small intestinal microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls
The results were based on the 16S rRNA sequencing
Time frame: 3 months
Sputum microbiota structure and function difference between active stage of Crohn's disease, remission of Crohn's disease and healthy controls
The results were based on the 16S rRNA sequencing
Time frame: 3 months
Metabolic difference of blood samples between active stage of Crohn's disease, remission of Crohn's disease and healthy controls
The metabolites of the blood samples by LC-MS will be detected
Time frame: 3 months
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