Phase 1 Trial for Tumor Treating Field for Drug/Radiation Resistant Brain Metastases

Inclusion Criteria: * patients are diagnosed as brain metastases by Xiangya Hospital multidisciplinary team; * age from 18 to 65 year-old; * patients have been progressed from standard therapy (drug/radiation resistance) * KPS more than 70 score; * anticipated OS more than 3 months; * signed consent form. Exclusion Criteria: * unable to take TTFields more than 18 hours each day; * unable to follow-up till progression; * the scalp wound is not well healed, the head skin condition is not good, the skull has a large area defect, or other situations that are not suitable for wearing electrodes * pregnant women; * last drug within 4 weeks, last radiation within 3 months, take other trials; * other heavy diseases like heavy infection; * other condition: Such as breastfeeding, installation of cardiac pacemakers, brain stimulators, severe intracranial edema, increased intracranial pressure leading to midline structures exceeding 5 mm, optic nerve head edema, disturbance of consciousness, etc., allergies to conductive coupling agents, gels, etc. * blood and biochemical indicators in the following range: A. Liver function impairment: AST or ALT \> 3 times the upper limit of normal; B. Total bilirubin\> upper limit of normal value; C. Renal impairment: serum creatinine\>1.7mg /dL (\>150 mol/L); D. Coagulopathy: PT or APTT \>1.5 times normal; E. Platelets counts \< 100x10\^9/L; F. Absolute neutrophils count \< 1x10\^9/L; G. Hemoglobin \< 100g/L; * other conditions physicians not suggest to take the trial