Phosphatidylserine is a phospholipid found in high concentrations in the brain and nervous tissues along with naturally occurring in many foods. It has been extensively studied for its effects on improving cognitive function, learning, memory and alleviating stress. However, more recently it has been proposed that phosphatidylserine could improve exercise capacity. The mechanisms of proposed action are difficult to distinguish because of the limited research and therefore the purpose of this study is to identify the proposed mechanism of action of phosphatidylserine supplementation and to establish whether these mechanisms will have an effect on time trial performance in trained male cyclists.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
20
800 mg per day for 10 days
30 minute cycling time-trial power output on an electromagnetically-braked cycle ergometer
Mean power output
Time frame: From baseline to 11 days post supplementation
Oxygen consumption at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
Evaluated using an online breath-by-breath gas analyser
Time frame: From baseline to 11 days post supplementation
Respiratory exchange ratio at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
Evaluated using an online breath-by-breath gas analyser
Time frame: From baseline to 11 days post supplementation
Breathing frequency at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
Evaluated using an online breath-by-breath gas analyser
Time frame: From baseline to 11 days post supplementation
Minute ventilation at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
Evaluated using an online breath-by-breath gas analyser
Time frame: From baseline to 11 days post supplementation
Blood lactate concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
Obtained via capillary puncture and analysed using an automated analyser
Time frame: From baseline to 11 days post supplementation
Blood glucose concentration at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
Obtained via capillary puncture and analysed using an automated analyser
Time frame: From baseline to 11 days post supplementation
Rating of perceived exertion at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
Evaluated using a 15-point (6-20) scale
Time frame: From baseline to 11 days post supplementation
Heart rate at four different exercise intensities (40, 50, 60 and 70% percent of maximal oxygen uptake) on an electromagnetically-braked cycle ergometer
Evaluated using a heart rate monitor
Time frame: From baseline to 11 days post supplementation
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