Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo

Momentum Data75,771 enrolled

Overview

This study examines melanoma and nonmelanoma skin cancer in people diagnosed with vitiligo compared to matched controls.

For the primary analysis, this study examines the risk of melanoma and nonmelanoma skin cancers: squamous cell carcinoma and basal cell carcinoma in people diagnosed with vitiligo. It also examines actinic keratoses. In secondary analysis, this study examines the prevalence of skin cancer in people diagnosed with vitiligo compared to matched controls. This study also examines whether the susceptibility to melanoma and nonmelanoma skin cancer may vary between different patient subgroups, e.g. ethnicity, those who undergo phototherapy or treatment with the new targeted biologic immunosuppressive therapies.

Study Type

OBSERVATIONAL

Enrollment

75,771

Conditions

Vitiligo Melanoma (Skin)Nonmelanoma Skin Cancer Squamous Cell Carcinoma Basal Cell Carcinoma Actinic Keratoses

Interventions

Exposure of skin cancer of interestOTHER

Melanoma and nonmelanoma skin cancers: squamous cell carcinoma, basal cell carcinoma and actinic keratoses.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All eligible adult patients (aged ≥ 18) registered with General Practioner (GP) practices contributing data to OPCRD between January 1, 2010 and December 31, 2020, were eligible for inclusion in the study. People diagnosed with vitiligo prior to the study period (prevalent vitiligo) and people newly diagnosed with vitiligo during the study period (incident vitiligo) are included as cases. Exclusion Criteria: * People actively registered with the GP practice at that date without a history of vitiligo require a minimum one-year registration with their GP practice.

Locations (1)

Momentum Data Ltd

London, United Kingdom

Outcomes

Primary Outcomes

Number of New Onset Skin Cancer in Adult People Diagnosed With Vitiligo

Number of new onset skin cancer assessed prospectively in vitiligo cases and matched controls. The skin cancer outcome comprises of the composite of melanoma and nonmelanoma skin cancers: squamous cell carcinoma and basal cell carcinoma.

Time frame: 10 years from the index date

Number of New Onset Skin Cancers in the Female Sex Subgroup

Number of new onset skin cancers assessed prospectively in female vitiligo cases and matched controls.

Time frame: 10 years from the index date

Number of New Onset Skin Cancers in the Male Sex Subgroup

Number of new onset skin cancers assessed prospectively in male vitiligo cases and matched controls.

Time frame: 10 years from the index date

Number of New Onset Skin Cancers in the <45 Age Subgroup

Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those aged \<45

Time frame: 10 years from the index date

Number of New Onset Skin Cancers in the 45-64 Age Subgroup

Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those aged 45-64

Time frame: 10 years from the index date

Number of New Onset Skin Cancers in the >=65 Age Subgroup

Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those aged \>=65

Time frame: 10 years from the index date

Number of New Onset Skin Cancers in the White Ethnicity Subgroup

Number of new onset skin cancers assessed prospectively in vitiligo cases and matched controls by those of white ethnicity

Data from ClinicalTrials.gov

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Secondary Outcomes

Prevalence of Skin Cancer in Adult People Diagnosed With Vitiligo

Skin cancer is defined as the composite of melanoma and nonmelanoma skin cancers: squamous cell carcinoma and basal cell carcinoma.

Time frame: At index date

Prevalence of Melanoma Skin Cancer in Adult People Diagnosed With Vitiligo

Prevalence of melanoma skin cancer in adult people diagnosed with vitiligo at or before recruitment

Time frame: At index date.

Prevalence of Squamous Cell Carcinoma Skin Cancer in Adult People Diagnosed With Vitiligo

Prevalence of squamous cell carcinoma skin cancer in adult people diagnosed with vitiligo at or before recruitment

Time frame: At index date.

Prevalence of Basal Cell Carcinoma Skin Cancer in Adult People Diagnosed With Vitiligo

Prevalence of basal cell carcinoma skin cancer in adult people diagnosed with vitiligo at or before recruitment

Time frame: At index date.

Number of New Onset Actinic Keratoses in Adult People Diagnosed With Vitiligo

Number of new onset actinic keratoses in adult people assessed in vitiligo cases and matched controls.

Time frame: 10 years from the index date

Prevalence of Actinic Keratoses in Adult People Diagnosed With Vitiligo

Prevalence of actinic keratoses in adult people diagnosed with vitiligo at or before recruitment

Time frame: At index date.