This study aims to investigate the incidence of venous thromboembolism in people who are diagnosed with atopic dermatitis.
The aim of this study is to examine whether venous thromboembolism is higher in people with atopic dermatitis compared and those without and to explore the risk in particular subgroups of people with AD such as those with higher body mass index or using oestrogen containing contraceptives. Such insights will be valuable for clinicians in advising patients with atopic dermatitis regarding venous thromboembolism prevention and detection and when selecting atopic dermatitis treatments.
Study Type
OBSERVATIONAL
Enrollment
754,745
Composite of pulmonary embolism and deep vein thrombosis
Momentum Data Ltd
London, United Kingdom
Number of Participants With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person.
To describe the risk of venous thromboembolism (composite of pulmonary embolism and deep vein thrombosis) in people with active AD compared to a matched control population.
Time frame: 10 years from index date
Number of Participants With Diagnosis of Pulmonary Embolism After the Start of Follow-up for Each Person
To describe the risk of pulmonary embolism in people with active AD compared to a matched control population.
Time frame: 10 years from index date
Number of Participants With Diagnosis of Deep-vein Thrombosis After the Start of Follow-up for Each Person
To describe the risk of deep-vein thrombosis in people with active AD compared to a matched control population.
Time frame: 10 years from index date
Number of Male Participants With Diagnosis of Risk of Venous Thromboembolism After the Start of Follow-up for Each Person
To explore the risk of VTE stratified by the male sex at the baseline in people with active AD compared to a matched control population.
Time frame: 10 years from index date
Number of Female Participants With Diagnosis of Risk of Venous Thromboembolism After the Start of Follow-up for Each Person
To explore the risk of VTE stratified by the female sex at the baseline in people with active AD compared to a matched control population.
Time frame: 10 years from index date
Number of Participants Aged 18-44 With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person
To explore the risk of VTE stratified by those aged 18-44 at the baseline in people with active AD compared to a matched control population.
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Time frame: 10 years from index date
Number of Participants Aged 45-64 With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person
To explore the risk of VTE stratified by those aged 45-64 at the baseline in people with active AD compared to a matched control population.
Time frame: 10 years from index date
Number of Participants Aged ≥65 With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person
To explore the risk of VTE stratified by those aged ≥65 at the baseline in people with active AD compared to a matched control population.
Time frame: 10 years from index date
Number of Participants BMI <30 With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person
To explore the risk of VTE stratified by those with a BMI \<30 at the baseline with active AD compared to a matched control population. Patients with active AD and missing BMI are excluded along with their related matched cases. Patients with active AD and no matched controls with BMI recorded are also excluded.
Time frame: 10 years from index date
Number of Participants BMI ≥30 With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person
To explore the risk of VTE stratified by those with a BMI ≥30 at the baseline in people with active AD compared to a matched control population. Patients with active AD and missing BMI are excluded along with their related matched cases. Patients with active AD and no matched controls with BMI recorded are also excluded.
Time frame: 10 years from index date
Number of Female Participants Aged 18-44 Using Oestrogen Contraceptive With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person
To explore the risk of VTE stratified by oestrogen contraceptive use in females aged 18-44 years at the baseline in people with active AD compared to a matched control population.
Time frame: 10 years from index date
Number of Participants Having History of an Allergic Condition With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person
To explore risk of VTE stratified by the presence, or absence of allergic conditions at baseline in people with active AD compared to a matched control population.. Allergic conditions will comprise common allergies; allergic rhinitis, allergy to dust mites or animal dander, and food allergies e.g., nut, fruit, shellfish, eggs and cows' milk allergies. Medication and other allergies will not be included.
Time frame: 10 years from index date