Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma

Siriraj Hospital5 enrolled

Overview

Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG). Setting: Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Study design: Prospective interventional case series Methods: PRP and IVA (2 mg/0.05 ml) injection were given, and TMC was performed within 2 weeks after IVA. Additional PRP, laser suture lysis, subconjunctival 5-fluorouracil injection, and bleb needling were performed after TMC if indicated. Best-collected visual acuity (BCVA), intraocular pressure (IOP), surgical complications, and number of anti-glaucoma medications were collected.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Intraocular Pressure Neovascular Glaucoma Vascular Endothelial Growth Factor Overexpression Glaucoma Secondary to Eye Inflammation

Interventions

Aflibercept OphthalmicDRUG

Panretinal photocoagulation and intravitreal aflibercept (2 mg/0.05 ml) injection were given, and trabeculectomy with mitomycin C was performed within 2 weeks after intravitreal aflibercept injection.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Consecutive patients with neovascular glaucoma who presented at the Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand during November 2018 to October 2019. * Aged more than 18 year-old Exclusion Criteria: * Patients who received any anti-vascular endothelial growth factor treatment before participation

Locations (1)

Naris Kitnarong

Bangkoknoi, Bangkok, Thailand

Outcomes

Primary Outcomes

Intraocular pressure

Intraocular pressure after trabeculectomy

Time frame: Post-operative on day 1st

Intraocular pressure

Intraocular pressure after trabeculectomy

Time frame: Post-operative on day 7th

Intraocular pressure

Intraocular pressure after trabeculectomy

Time frame: Post-operative on month 3rd

Intraocular pressure

Intraocular pressure after trabeculectomy

Time frame: Post-operative on month 6th

Intraocular pressure

Intraocular pressure after trabeculectomy

Time frame: Post-operative on month 12th

Intraocular pressure

Intraocular pressure after trabeculectomy

Time frame: Post-operative on month 18th

Intraocular pressure

Intraocular pressure after trabeculectomy

Time frame: Post-operative on month 24th

Intraocular pressure

Intraocular pressure after trabeculectomy

Time frame: Post-operative on month 30th

Intraocular pressure

Intraocular pressure after trabeculectomy

Time frame: Post-operative on month 36th