The purpose of this research is to the determine effect of dry eye and to compare the effect of artificial tears on central and peripheral corneal thickness.
In this randomized controlled trial, 96 eyes of females with dry eye will be recruited through random sampling. Dry eye assessments will be done including TBUT, Schirmer test 1, and OSDI questionnaire. 96 eyes will be divided into 3 groups (32 eyes each) and will be provided intervention which is Polyethylene Glycol 400 0.4%-Propylene Glycol 0.3%. , Dextran 0.1%Hypromellose 0.3%, and placebo(normal saline) through randomization by an unmasked investigator. Changes in central and peripheral corneal thickness will be evaluated by corneal topography. Patients will be evaluated at baseline, after 15 days, after 1 month, and re-evaluated after 1 month of cessation of treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
96
Drugs will be given to two group and third group will kept on placebo.
The University of Faisalabad
Faisalabad, Punjab Province, Pakistan
Change in Corneal Thickness in microns
effect of dry eye treatment on the thickness of the cornea in microns measured by using corneal topography.
Time frame: one month
Change in Corneal Thickness in microns after treatment discontinuation.
after on month of treatment discontinuation access the change in corneal thickness in microns by using corneal topography.
Time frame: one month
Improvement in dry eye
after treatment with artifical tears improvement in the tear break-up time in seconds and schirmer test values in millimeters.
Time frame: one month
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