The aim of this recall study is to evaluate outcomes of surgical regenerative treatment of periodontal defects in a cohort of patient previously treated for gum disease at the Royal London Hospital as part of their periodontal care.
This study will be divided in two parts: Part 1: a retrospective analysis of short-term outcomes of periodontal regenerative procedures undertaken at the Barts Royal London Dental Hospital (RLDH); Part 2: a single recall visit study in which patients identified through part 1 and willing to consent for the study will be reassessed for medium-term outcomes of the regenerative procedures previously undertaken. For part 1 historic data will be collected from available dental records at RLDH and divided in: * Timepoint 0: the latest available full mouth periodontal assessment before surgery and x-ray of site/s needing surgical intervention * Timepoint 1: the latest available full mouth periodontal assessment after surgery and x-ray of same site/s at Timepoint 0 For part 2 data will be collected from patients identified through part 1 and willing to give consent for a single study recall visit: •Timepoint 2: single study outcome recall visit (full mouth periodontal assessment and x-ray of same site/s at Timepoint 0). Due to the nature of the study, the time elapsed between Timepoint 0 and Timepoint 2 can vary between 1 and 4 years.
Study Type
OBSERVATIONAL
Enrollment
200
Barts Health NHS Trust Dental Hospital
London, United Kingdom
% of patients with pocket closure at worst site per mouth for intrabony defects
Pocket closure is defined as PPD \< and = 4 mm with no bleeding on probing (BoP)
Time frame: Through study completion, an average of 2 years
% of patients with pocket closure at worst site per mouth for intrabony defects
Secondary outcome
Time frame: Measured at Timepoint 1 (from 6 months up to 1 year)
Changes in periodontal probing pocket (PPD) for intrabony defects at site and patient level.
Secondary outcome
Time frame: Changes measured from baseline (Timepoint 0) to Timepoint 1( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Changes in clinical attachment level (CAL) for intrabony defects at site and patient level.
Secondary outcome
Time frame: Changes measured from baseline (Timepoint 0) to Timepoint 1( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Changes in horizontal furcation involvement
Secondary outcome
Time frame: Changes measured from baseline (Timepoint 0) to Timepoint 1( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Changes in vertical CAL for furcation defects
Secondary outcome
Time frame: Changes measured from baseline (Timepoint 0) to Timepoint 1( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Change in diagnosis of periodontal disease
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Secondary outcome
Time frame: Changes measured from baseline (Timepoint 0) to Timepoint 1( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Radiographic bone levels changes at site level
Secondary outcome
Time frame: Changes measured from baseline (Timepoint 0) to Timepoint 1( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Radiographic bone levels changes at tooth level
Secondary outcome
Time frame: Changes measured from baseline (Timepoint 0) to Timepoint 1( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Tooth loss
Secondary outcome
Time frame: Changes measured from baseline (Timepoint 0) to Timepoint 1( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Correlation of pocket closure to type of surgical approach used (minimally invasive approach, papilla preservation flaps, conventional flaps)
Secondary outcome- Measured as % of sites with pocket closure (PPD\< and = 4mm with no BoP)
Time frame: Assessed at Timepoint 1 ( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Correlation of pocket closure to biomaterials used
Secondary outcome- Measured as % of sites with pocket closure (PPD\< and = 4mm with no BoP)
Time frame: Assessed at Timepoint 1 ( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Correlation of pocket closure to diabetes status
Secondary outcome- Measured as % of sites with pocket closure (PPD\< and = 4mm with no BoP)
Time frame: Assessed at Timepoint 1 ( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Correlation of pocket closure to smoking history
Secondary outcome- Measured as % of sites with pocket closure (PPD\< and = 4mm with no BoP)
Time frame: Assessed at Timepoint 1 ( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Correlation of pocket closure to supportive periodontal therapy frequency
Secondary outcome- Measured as % of sites with pocket closure (PPD\< and = 4mm with no BoP)
Time frame: Assessed at Timepoint 1 ( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)
Correlation of pocket closure to level of clinician's experience
Secondary outcome- Measured as % of sites with pocket closure (PPD\< and = 4mm with no BoP)
Time frame: Assessed at Timepoint 1 ( from 6 months up to 1 year) and Timepoint 2 (through study completion, an average of 2 years)