A Proof of Concept Study of Pan-cancer Early Detection by Liquid Biopsy

Inclusion Criteria for Cancer Arm Participants: * Ability to provide a written informed consent * 40-75 years old * Ability to comply with study procedures * Confirmed diagnosis or suspicious cases of one of the 9 types of cancers within 42 days prior to study blood draw. * No prior anti-cancer therapy (local or systematic) prior to study blood draw Exclusion Criteria for Cancer Arm Participants: * Pregnancy or lactating women * Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant * Recipients of blood transfusion within 7 days prior to study blood draw * Recipients of any anti-cancer therapy within 30 days prior to study blood draw, due to diseases other than cancer * Known prior diagnosis of malignancies, other current malignant diseases or multiple primary tumors * No confirmed diagnosis of cancer by histopathological or radiological assessments within 42 days of study blood draw, or diagnosis of a benign disease or precancerous lesions by histopathological assessments, or inability to characterize whether the lesion is malignant or benign Inclusion Criteria for Healthy Arm Participants: * Ability to provide a written informed consent * 40-75 years old * No cancer-related symptoms or discomfort within 30 days prior to study blood draw * Ability to comply with study procedures * No clinically significant finding by laboratory tests and radiology examinations Exclusion Criteria for Healthy Arm Participants: * Pregnancy or lactating women * Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant * Recipients of blood transfusion within 7 days prior to study blood draw * Clinically significant or uncontrolled comorbidities * Prior or ongoing treatment of cancer within 3 years prior to study blood draw