This study examines how electronic (e)-cigarette use impacts the body, by studying both users and non-users of e-cigarettes. Early evidence indicates that e-cig users experience adverse health effects. Results of this study may help policy-makers develop standards for different types of tobacco.
PRIMARY OBJECTIVE: Examine the short-term impacts of vaping on pulmonary and respiratory outcomes. OUTLINE: Current e-cigarette users will vape their own e-cigarette device ad libitum for 30 minutes; non-users will watch a neutral video for 30 minutes. Before and after the 30 minute vaping \[video\] session, participants will undergo the following assessments: computer-based spirometry testing, nitric oxide breath testing, airwave oscillometry, and an assessment of endothelial function. Participants will also undergo collection of blood.
Study Type
OBSERVATIONAL
Enrollment
182
Undergo collection of blood
Undergo nitric oxide breath testing
Undergo airwave oscillometry
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
Airway inflammation as assessed by exhaled nitric oxide
Exhaled nitric oxide will be measured in parts per billion (ppb)
Time frame: Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes)
Airway reactivity as assessed by airwave oscillometry
Airway reactivity will be measured via Tremoflo, which is a well validated measurement of airway reactivity and provides curves of Resistance (R) and Reactance (X)
Time frame: Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes)
Respiratory functioning as assessed by a mobile Spirometry device
Spirometry will collect daily data from participants on the relationship between their forced expiratory volume and forced vital capacity (measured as FEV1/FVC).
Time frame: Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes)
Endothelial function
Endothelial function will be assessed with the EndoPAT device (unit of measurement = LnRHI).
Time frame: Procedure will last approximately 20 minutes; the procedure will occur twice during the laboratory session (separated by approximately 90 minutes)
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Undergo spirometry
Complete survey
Endothelial function will be assessed with the EndoPAT device, which measures changes in pressure from sensors placed on the fingertip