Ocular Comorbidity in Atopic Dermatitis

N/AActive Not RecruitingNCT04973384

Rigshospitalet, Denmark120 enrolled

Overview

A clinical characterization of a large cohort of patients with different severities of AD and ocular symptoms/atopic keratoconjunktivitis (AKC). The data will contribute to assess the frequency of complications in order to give a rationale for focused prevention and treatment strategy.

Atopic Dermatitis (AD), a very common inflammatory skin condition of child and adulthood, is strongly associated with ocular disease. Accordingly, about 20% experience conjunctivitis at some point, and many have chronic disease. Atopic keratoconjunctivitis (AKC) is the most feared as it may lead to blindness. Little is known about the etiology, the immune infiltrate, as well as predictive factors of AKC and the clinical characteristics of AD patients who develop this entity. We expect this project to enable clinicians to better identify AKC patients in the future as well as improve the understanding of the pathogenesis of AKC. The ocular findings will be compared between AD severity and a control group without ocular symptoms.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Atopic Keratoconjunctivitis

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Danish talking * Diagnosed with atopic dermatitis (AD) * Current or previous ocular symptoms suspected to be atopic keratoconjunctivitis Exclusion Criteria: * No pause in eyedrops * Ocular infections within the last 3 months * Use of local or systemic antibiotics within the last 3 months * Significant untreated systemic disease such as hypertension, heart failure, diabetes mellitus, previous cerebral infarction or bleeding, lung diseases and autoimmune diseases other than atopic dermatitis and related comorbidities. The diseases are accepted if they are well treated or do not require treatment * Current pregnant or breastfeeding * Use of contact lenses, unless these are paused 2 weeks before the examination or they are due to keratoconus treatment * If the eye symptoms turn out not to be related to atopic keratoconjunctivitis * If it is assessed that the individual cannot participate sufficiently for the examination

Locations (1)

Department of Ophthalmology, Rigshospitalet-Glostrup

Glostrup Municipality, Denmark

Outcomes

Primary Outcomes

Bulbar redness (BR) score

Difference in Bulbar redness (BR) score (Keratograph 5M, R-scan). Scale from 0-4. A higher score indicates more severe BR.

Time frame: 1 day At examination