The purpose of this study is to explore the optimal sequence of same-day bidirectional endoscopy under deep anesthesia induced by propofol combined with fentanyl.
Same-day bidirectional endoscopy are commonly performed to evaluate iron deficiency anemia, positive fecal occult blood, abdominal pain and cancer screening. In order to reducing intraoperative pain, providing better operating conditions and improving the endoscopic examination quality, endoscopy with anesthesia assistance has gradually become the choice of more patients. However, the optimal sequence of procedures for same-day bidirectional endoscopy has not been established. This is a two-center, single-blind, randomized, controlled trial. Patients undergoing same-day bidirectional endoscopy under deep sedation will be randomly assigned to either the colonoscopy-first group (colonoscopy followed by EGD, n = 272) or the EGD(esophagogastroduodenoscopy)-first group (EGD followed by colonoscopy, n = 272).The detection rate of adenoma（ADR）, the ADR of right-side colon , Boston score of right-side colon, total dose of anesthetics, operation time, recovery time, adverse events and patient satisfaction will be evaluated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
544
In this group, patients receiving an EGD followed by a colonoscopy during a same-day bidirectional endoscopy. Patients receive deep sedation with propofol and fentanyl.
In this group, patients receiving a colonoscopy followed by EGD during a same-day bidirectional endoscopy. Patients receive deep sedation with propofol and fentanyl.
Adenoma Detection Rate
Adenoma detection rate is the proportion of individuals undergoing a complete screening colonoscopy who have one or more adenomas detected. In this study, ADR during the colonoscopy will recorded.
Time frame: 1 year
Adenoma Detection Rate of the right-sided colon
The ADR of right-sided colon will be recorded.Right -sided colon is refered to cecum, ascending colon and ileocecal junction.
Time frame: 1 year
The boston bowel preparation scale of the right-sided colon
During colonoscopy, the boston bowel preparation scale of the right-sided colon will be recorded and compared between the two study groups.
Time frame: 1 year
Sedation use
During bidirectional endoscopy, the total doses of propofol and fentanyl will be recorded.
Time frame: 1 year
Overall Duration of BDE Examinations
The overall duration of both EGD and colonoscopy examinations will be recorded.
Time frame: 1 year
Recovery time
Time between the end of the procedure and patient waken-up will be recorded.
Time frame: 1 year
Adverse events
Intraprocedure adverse events will be documented (oxygen saturation \<90% for \>30 s, systolic blood pressure drop for 30 %, and heart rate \<50 or \>120 beats/min lasting \>30 s).
Time frame: 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Overall patient satisfaction
Patient satisfaction will be assessed after the procedures using 10-cm visual analog scale.
Time frame: 1 year