Gluten sensitivity is the most common auto-immune disease associated with auto-immune thyroiditis. This association is through elevated anti-Tissue transglutaminase (Anti-tTG) levels both in Celiac disease and thyroiditis. In our study we tried to find if there is any correlation in between Anti-tTG and degree of fibrosis in thyroid tissue (Post-operative specimen).
Most common auto-immune disease associated with Celiac disease is autoimmune thyroiditis. This association in between Celiac disease and aout-immune thyroiditis is related with asymptomatic rise in anti-tTG levels. In our study, we planned to show that if there is any correlation of thyroiditis related fibrosis in thyroid tissue with anti-tTG IgA ( immune-globulin A) and IgG (immune-globulin G).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
198
Examination of pathology specimen and laboratory measuring
SBU Diskapi Yildirim Beyazit Training and Research Hospital
Ankara, Turkey (Türkiye)
Amount of fibrosis in thyroid tissue and measured level of anti-tTG levels in serum
Degree of fibrosis was defined after painting of slides with masson trichrome as absent, mild, moderate semi-quantitatively.
Time frame: one day after operation
Measurement of Anti-tTG levels in serum
Amount of serum Anti-TG in IU/mL
Time frame: one day after operation
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