The aims of this study are to 1. Assess the preoperative and postoperative atrial and ventricular structure and function comprehensively in heart transplantation; 2. Explore the early, accurately and non-invasively indicators for evaluating myocardial fibrosis in end-stage heart failure, as well detecting acute rejection (AR),coronary allograft vasculopathy(CAV) and adverse clinical events in heart transplant patients by using conventional and the advanced echocardiography.
This study will enrolled 1000 HT patients and 500 healthy controls, and the cardiac structure and function will be evaluated by ultrasound multimodal imaging. And the study aimed to 1. Assess the preoperative and postoperative atrial and ventricular structure and function comprehensively in heart transplantation; 2. Explore the early, accurately and non-invasively indicators for evaluating myocardial fibrosis in end-stage heart failure, as well detecting acute rejection(AR),coronary allograft vasculopathy(CAV) and adverse clinical events in heart transplant patients by using conventional and the advanced echocardiography.
Study Type
OBSERVATIONAL
Enrollment
1,500
Using Image-Pro Plus 6.0 software to measure myocardial fibrosis
The extent of myocardial fibrosis of the myocardial tissue from the removed heart during heart transplant was measured by Image-Pro Plus 6.0 software up to 1 year after heart transplant
Time frame: the measurement of myocardial fibrosis up to 1 year after heart transplant
All cause death after the inclusion of the study
All cause death after HT was obtained via telephone interview with family members; contact with his/her physicians; or hospital records every year
Time frame: All cause death happened after inclusion of this study, up to 5 years
Acute rejection after the inclusion of the study
Acute rejection after the inclusion of the study was obtained at regular intervals via telephone interview with the patient, or if deceased, with family members; contact with his/her physicians; or hospital records every year
Time frame: Acute rejection happened after inclusion of this study, up to 5 years
Cardiac allograft vasculopathy after the inclusion of the study
Cardiac allograft vasculopathy after the inclusion of the study was obtained at regular intervals via telephone interview with the patient, or if deceased, with family members; contact with his/her physicians; or hospital records every year
Time frame: Cardiac allograft vasculopathy happened after inclusion of this study, up to 5 years
Major adverse cardiac events after the inclusion of the study
Major adverse cardiac events after the inclusion of the study was obtained at regular intervals via telephone interview with the patient, or if deceased, with family members; contact with his/her physicians; or hospital records every year
Time frame: Major adverse cardiac events happened after inclusion of this study，up to 5 years
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