Early Warning Model of Susceptibility and High-risk Population of Cervical Cancer Related to HPV

Huazhong University of Science and Technology20,000 enrolled

Overview

Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to establish an early warning model for a high-risk population of cervical cancer.

Study Type

OBSERVATIONAL

Enrollment

20,000

Conditions

Uterine Cervical Neoplasm Uterine Cervical Cancer Cervical Cancer

Eligibility

Sex: FEMALEMin age: 25 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * (1) Case group a) Aged 25-75 years. b) Han nationality. c) Patients with cervical cancer or cervical precancerous lesions above CIN2 diagnosed by biopsy or postoperative pathological diagnosis. * (2) Control group: a) Aged 25-75 years. b) Han nationality. c) No family history of cervical cancer or precancerous lesions. d) The results of TCT examination showed no abnormality. Exclusion Criteria: * (1) suffering from other neoplastic diseases. * (2) pregnant women. * (3) those with a history of bone marrow transplantation.

Early Warning Model of Susceptibility and High-risk Population of Cervical Cancer Related to HPV

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts