Effect of Coffeeberry on Mood, Motivation and Cognitive Performance

PepsiCo Global R&D30 enrolled

Overview

The primary purpose is to test the short-term effects of the acute consumption of two novel beverages made from coffeeberries, the fruit of the coffee plant (Coffea arabica) benchmarked against caffeine on several aspects of cognitive performance. Preliminary studies suggest that flavanols and chlorogenic acids can enhance cognitive performance. It is unknown if drinks formulated with flavanols and chlorogenic acids (without high sugar or caffeine) improve cognition or mood to a similar extent as caffeine. Coffeeberry beverage comparisons will be made to a flavored positive control beverage containing caffeine and a flavored placebo beverage.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Fatigue, Mental Alertness Mood Motivation Cognitive Performance

Eligibility

Sex: ALLMin age: 17 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Are older than 17 and under 50 years of age * Self-report of good health Exclusion Criteria: * Using any prescription medication including birth control * Report hypersensitivity to caffeine * Have visual impairment that cannot be corrected with glasses or contact lenses * Report any food allergies * Self-reported excessive leisure time physical activity (\> 7 strenuous bouts per week) * the presence of current gastrointestinal, sleep, or psychiatric disorder, * Report pregnancy/lactation, illegal drug use, smoker * failure to demonstrate adequate minimal performance on lab, computer-based cognitive tasks. * Participation in another clinical trial within past 30 days

Outcomes

Primary Outcomes

Cognition score

Objective Cognitive Demand Battery (CDB) using Computerised Mental Performance Assessment framework tasks (COMPASS) for word and picture presentation and recall, serial 3 and 7 subtraction, Rapid Visual Information Processing (RVIP).

Time frame: Change from baseline to 60 and 120 min post-consumption. Higher test scores are better.

Fatigue score

Subjective Visual Analog Scale (VAS) rating from 1-100 mm from not at all to extremely, during Cognitive Demand Battery (CDB) using Computerised Mental Performance Assessment framework tasks (COMPASS)

Time frame: Change from baseline to 60 and 120 min post-consumption. Lower fatigue score is better.

Alertness score

Subjective Bond-Lader Visual Analog Scale (VAS) rating from 1-100 mm representing the full range of each dimension from not at all to extremely, during Cognitive Demand Battery (CDB) Visual Analog Scale (VAS) rating from 1-100 mm during Cognitive Demand Battery(CDB) within Computerised Mental Performance Assessment framework tasks (COMPASS)

Time frame: Change from baseline to 60 and 120 min post-consumption. Higher alertness score is better.

Calmness score

Subjective Bond-Lader Visual Analog Scale (VAS) rating from 1-100 representing the full range of each dimension from not at all to extremely, during Cognitive Demand Battery (CDB)during Cognitive Demand Battery (CDB) Visual Analog Scale (VAS) rating from 1-100 mm during Cognitive Demand Battery(CDB) within Computerised Mental Performance Assessment framework tasks (COMPASS)

Time frame: Change from baseline to 60 and 120 min post-consumption. Higher calmness score is better.

Contentedness score

Subjective Bond-Lader Visual Analog Scale (VAS) rating from 1-100 mm representing the full range of each dimension from not at all to extremely, during Cognitive Demand Battery (CDB)during Cognitive Demand Battery (CDB) Visual Analog Scale (VAS) rating from 1-100 mm during Cognitive Demand Battery(CDB) within Computerised Mental Performance Assessment framework tasks (COMPASS)

Time frame: Change from baseline to 60 and 120 min post-consumption. Higher contentedness score is better.

Motivation score

Subjective Visual Analog Scale (VAS) rating from 1-100 mm from not at all to extremely, during Cognitive Demand Battery (CDB) within Computerised Mental Performance Assessment framework tasks (COMPASS)

Time frame: Change from baseline to 60 and 120 min post-consumption. Higher motivation score is better.

Energy score

Subjective mental and physical state energy and fatigues scales (EFS-State Scale). Composite scores range from 0 to 300 mm, from feelings of no energy to strongest feelings of energy during Cognitive Demand Battery (CDB) using Computerised Mental Performance Assessment framework tasks (COMPASS)

Time frame: Change from baseline to 60 and 120 min post-consumption. Stronger feelings of mental and physical energy are better.