Characterization and Pathogenesis of ACLF

Johann Wolfgang Goethe University Hospital1,000 enrolled

Overview

This single-center prospective observational study aims at characterization of pathogenesis of ACLF. There will be three different cohorts investigated with the main endpoint mortality in these groups. 1. SAPIENT = Sepsis ACLF patients, to investigate the differences between ACLF and sepsis in cirrhosis 2. PROACT = Portal mediators as ACLF Targets, to assess portal venous biomarkers in patients receiving TIPS leading to ACLF and identify potential treatment targets 3. ELITE = prEdictors of beneficial LIver Tx in ACFL patiEnts, to assess in ACLF-patients receiving liver transplantation predictors of survival, which may improve selection of ACLF-patients for liver transplantation Secondary endpoints will be different in the three different cohorts and biological material will be collected for separate ancillary studies.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Liver Cirrhosis Acute-On-Chronic Liver Failure Portal Hypertension

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Liver cirrhosis Exclusion Criteria: * extrahepatic and metastatic malignancy, * refusal for participation * decision of attending phycisian

Characterization and Pathogenesis of ACLF

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Central Contacts