High Protein Intake in Critically Ill Ventilated Patients

Cairo University40 enrolled

Overview

This prospective interventional randomized control study was conducted on forty patients with respiratory failure; all patients were intubated and mechanically ventilated for at least three days. Twenty patients received high protein intake using whey protein, with daily follow-up of the blood sugar level, serum electrolytes, and chemistry. ICU outcome regarding food intolerance, 30-day mortality, length of MV and ICU-stay was recorded

Study Type

OBSERVATIONAL

Enrollment

Conditions

Intensive Care Unit Syndrome

Interventions

Whey proteinDIETARY_SUPPLEMENT

Patients were randomly divided into two groups: Group (A): Enteral feeding with normal protein intake ( 1.0 gm pin /kg/day ) Group (B): Enteral feeding with high protein intake ( 1.5- gm open /kg/day ) -Patient's- nonprotein- caloric intake was calculated according to REE :(25xactual body weight in kg ) and received it as follow : 1/2 the calculated amount of caloric intake in DAY 1 3/4 of the calculated amount of caloric intake in DAY 2 -Full calculated caloric amount in DAY 3 This regimen was followed long as the patient was tolerating the amount of feeding, and in case of intolerance: The volume of feeding boluses was decreased or Increase the time interval between boluses or IV metoclopramide or erythromycin was given

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \>18 years * Mechanically ventilated patients (for three days or more ) Exclusion Criteria: * Age \< 18 years old * Contraindication for enteral nutrition (gut ischemia, obstruction, or perforation) * Expected intolerance for enteral nutrition (paralytic ileus) * Inability to start enteral nutrition within 24-hours(i.e. surgery or other interventions) * Short bowel syndrome * Hemodynamic instability ( i.e shock state, need for vasopressors ) * Child C liver cirrhosis or acute liver failure * Dialysis dependency

Locations (1)

Cairo University Hospitals

Cairo, Egypt

Outcomes

Primary Outcomes

Effect of high protein intake on glycemic control

measurements of blood glucose levels regularly after high protein intake

Time frame: up to 7 days

Effect of high protein intake on serum electrolytes

measurements of Na, K, Mg, phosphorous and calcium levels regularly after high protein intake

Time frame: up to 7 days

Secondary Outcomes

Effect of high protein intake on ICU outcome

ICU outcome includes ICU survival , mechanical ventilation , food intolerance

Time frame: up to 7 days

Data from ClinicalTrials.gov

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