Eccentric Resistance Training With Blood Flow Restriction on Muscle Function

Utah State University

Overview

The study will determine the effects of adding blood flow restriction to eccentric training to assess whether this increases the improvements of muscle strength and size.

Subjects will be randomly assigned to two groups: an eccentric only resistance training group or an eccentric training plus blood flow restriction group. Subjects will train at a moderately low intensity on a multiple-joint eccentric device. Those in the blood flow restriction will wear blood flow restriction cuffs on their upper thighs to reduce blood flow during the brief protocol. The training session will occur twice per week and will last \~5 minutes, including a one minute warm up, a one minute cool down and a three minute workout phase. The training program will last 7 weeks. Testing will be conducted at baseline (following a one session familiarization), 4 weeks and after the end of the 7 week training period. Assessments will focus on muscle strength, function, and morphology (size).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Conditions

Blood Flow Restriction

Interventions

ExerciseOTHER

The interventions are a form or exercise, specifically resistance exercise.

Eccentric plus blood-flow restrictionOTHER

Eccentric plus blood-flow restriction

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-30 years of age * currently engaged in some form of resistance training between 1-3 times per week * must have been training aerobically, but no more than 3 hours a week for the past six months Exclusion Criteria: * Must not have had any surgery of the lower limbs within the past 1 year period * Must not have any neuromuscular disorder (e.g., Muscular dystrophy etc.) * \< 76 inches tall (in order to fit on the training machine) * Maximal strength of \< 725 lbs for the eccentric training device * If any of the subjects are pregnant or plan to be pregnant in the duration of the protocol. For those randomized to the BFR group, if any of the subject's thighs are too large for the BFR cuffs (greater than 68 cm).

Locations (1)

Utah State Universtiy

Logan, Utah, United States

Outcomes

Primary Outcomes

Eccentron maximal muscle strength

Eccentric muscle strength will be assessed via Eccentron (BTE Technologies, Inc., USA), an seated isokinetic dynamometer.

Time frame: 7 weeks

Local muscle hypertrophy

Muscle size changes of the quadriceps muscle measured an ultrasound device (GE NextGen LOGIQ, Tampa, Florida, USA).

Time frame: 7 weeks

Muscle mass

dual energy x-ray absorptiometry device (DEXA) the Hologic Horizon W Dual X-ray absorptiometry (Hologic Canada ULC, Mississauga, ON, Canada) will be used to assess appendicular (lower body) mean mass.

Time frame: 7 weeks

Muscle function

Vertical jump height will assess 3 maximal countermovement attempts on a jump mat (Just Jump Technologies, Huntsville, AL, USA) that measures jump height based on flight time.

Time frame: 7 weeks

Secondary Outcomes

Muscle soreness

local muscle soreness will be assessed throughout the duration of the intervention period using a Wagner force algometer.

Time frame: 7 weeks

Data from ClinicalTrials.gov

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