Safety and Efficacy Study of Remote Ischemic Conditioning Combined With Endovascular Thrombectomy for Acute Ischemic Stroke Due to Large Vessel Occlusion of Anterior Circulation

Inclusion Criteria: * 1\) Age ≥ 18 years, male or female * 2\) Diagnosis of acute ischemic stroke within 24 hours of symptom onset and underwent endovascular thrombectomy (EVT) adhering to current guidelines for large vessel occlusion in the anterior circulation (confirmed by computed tomography angiography or digital subtraction angiography) * 3\) Pre-EVT NIHSS ≥ 6 * 4\) Premorbid mRS ≤ 2 * 5\) Written informed consent obtained from the patient or legally responsible person Exclusion Criteria: * 1\) Contraindication of endovascular thrombectomy * 2\) Contraindication of remote ischemic conditioning, such as severe soft tissue injury, fracture, or vascular injury in the upper limb, acute or subacute venous thrombosis, arterial occlusive disease, and subclavian steal syndrome * 3\) Head CT showing cerebral hernia and midline displacement * 4\) Pregnancy or lactation * 5\) Previous remote ischemic conditioning therapy or similar treatment * 6\) Severe hepatic and renal dysfunction * 7\) Life expectancy of less than 3 months or inability to complete the study for other reasons * 8\) Unwilling to be followed up or poor compliance * 9\) Current or past participation in other clinical research, or participation in this study within 3 months prior to admission * 10\) Other conditions that the researchers think make the patient unsuitable for the study