PVI for TVC Response

National Taiwan University Hospital50 enrolled

Overview

Determine the ability of changes in Plethysmographic Variability Index during tidal volume challenge to predict fluid responsiveness

The change of Plethysmographic Variability Index after tidal volume challenge as a predictor of fluid responsiveness, confirmed with the change of SVV using Flotrac advance cardiac output monitor. To determine whether the patient is fluid responder, Fluid challenge will be performed afterwards to confirm the patient's fluid responsiveness. We also aim to calculate the least significant change for Plethysmographic Variability Index and Philips PPV system.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Validation of PVI in Tidal Volume Challenge Test

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion: Patients undergoing elective major surgery (estimated \> 2-hr) with general anesthesia and mechanical ventilation in supine position Exclusion: 1. BMI \< 18.5 or \>30 kg/m2 2. Pregnant patient 3. Allergy to starch solution 4. estimated glomerular filtration rate\< 60

Locations (1)

National Taiwan University Hospital

Taipei, Taiwan

RECRUITING

Outcomes

Primary Outcomes

The predictive ability of change in Plethysmographic Variability Index after Tidal volume challenge to predict fluid responsiveness

The change in value of Plethysmographic Variability Index after increasing VTE from 6 ml/kg to 8 ml/kg.

Time frame: 20 minutes

Secondary Outcomes

Least significant change for Massimo PVI and Philips PPV

Calculate the least significant change for Massimo PVI and Philips PPV using data acquired from our electronic system

Time frame: 20 minutes

Central Contacts

Chun-Yu Wu

CONTACT

0972653376 longersolo@gmail.com

Data from ClinicalTrials.gov

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