The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat. These conditions reduce operational effectiveness and expose personnel to a risk of incapacitation and death from exertional heat illness (EHI). The aim of this study is to examine traditional and novel risk factors that may increase thermal strain and EHI likelihood in military recruits undergoing strenuous physical exercise.
Study Type
OBSERVATIONAL
Enrollment
783
Core temperature will be monitored on the day of exercise
Questionnaires will be completed at baseline and on the day of exercise
Heart rate will be monitored on the day of exercise
Commando Training Centre Royal Marine
Lympstone, Devon, United Kingdom
Body mass index in EHI and control group
Time frame: Baseline
Fitness in EHI and control group - participants ranked by time to complete fitness test
Time frame: Baseline
Core temperature in EHI and control group
Time frame: 1 Day
Heart rate in EHI and control group
Time frame: 2 Hours
Urine osmolality in EHI and control group
Time frame: Baseline
Sleep quality and quantity, measured by Pittsburgh Sleep Quality Index, in EHI and control group
0-21 Scale. Higher score indicates worse outcome
Time frame: Throughout study - up to 1 week
Sleep quality, measured by actigraphy, between EHI and control group
Time frame: Throughout study - up to 1 week
Sleep quantity, measured by actigraphy, between EHI and control group
Time frame: Throughout study - up to 1 week
Circulating Interleukin 6 in EHI and control group
Time frame: Baseline
Circulating C-Reactive Protein in EHI and control group
Time frame: Baseline
Circulating Creatine kinase in EHI and control group
Time frame: Baseline
Circulating Aspartate Aminotransferase in EHI and control group
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Urine samples will be collected at baseline and on the day of exercise
Sleep will be monitored at baseline and on the day of exercise
Blood samples will be completed at baseline
Saliva samples will be collected at baseline and on the day of exercise
Throat swab samples will be collected at baseline and on the day of exercise
Stool samples will be collected at baseline and on the day of exercise
Time frame: Baseline
Circulating Alanine Aminotransferase in EHI and control group
Time frame: Baseline
Circulating Claudin 3 in EHI and control group
Time frame: Baseline
Circulating Zonulin in EHI and control group
Time frame: Baseline
Circulating Lipopolysaccharide binding protein in EHI and control group
Time frame: Baseline
Circulating immunoglobulin E in EHI and control group
Time frame: Baseline
Salivary cortisol in EHI and control group
Time frame: Throughout study - up to 1 week
Detection of infectious pathogens in EHI and control groups
Time frame: Throughout study - up to 1 week
Respiratory illness symptomology, measured by Jackson common cold questionnaire, in EHI and control group
0-24 Scale. Higher score indicates worse outcome
Time frame: Throughout study - up to 1 week
Gastrointestinal illness symptomology, measured by gastrointestinal symptoms questionnaire, in EHI and control group
0-10 Scale per symptom. Higher score indicates worse outcome
Time frame: Throughout study - up to 1 week
Abundance and diversity of gastrointestinal microbiota in EHI and control group
Time frame: Baseline