REnal TRansplant Outcomes After CARdiac Surgery (RETROCAR)

University Hospital, Bordeaux93 enrolled

Overview

In this retrospective study, the authors assess long term renal outcome in renal transplant recipients after cardiac surgery with cardiopulmonary bypass, and research factors associated with poor long term renal outcome.

Post-operative mortality after cardiac surgery is increased in renal transplant recipients, compared with general population of cardiac surgery, or with kidney transplant recipients not undergoing cardiac surgery. If the survival of this specific population is now well studied, the long-term renal outcome is much less studied. Previous studies show a trend for increased risk of allograft dysfunction and need for permanent dialysis. This study proposes to compare long term renal outcome between renal transplant recipients and non-renal transplant recipients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiac Surgery Cardiopulmonary Bypass Renal Transplant Recipient

Interventions

standard of careOTHER

retrospective study : standard of care

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria for Renal Transplant Recipients group: * Previous renal transplantation * Who underwent cardiac surgery with CPB Inclusion Criteria for Non Renal Transplant Récipients group: * No previous renal transplantation * Who underwent cardiac surgery with CPB * Apparied with Renal Transplant récipients with the 5 following criteria : age, sex, previous diagnosis of diabete, type of cardiac surgery (isolated coronary artery bypass graft, valvular surgery, aorta surgery, combined surgery), best glomerular filtration rate with CKD-EPI formula at +/- 15 ml/min, in the 3 pre-operative months Exclusion Criteria: * Patients requiring mechanical circulatory support (Extracorporeal Membrane Oxygenation) * Pre-operative permanent dialysis * Aorta dissection extended to renal arteries * Non-elective surgery for infective endocarditis * Previous hepatic, pancreatic or cardiac transplantation * Death in the 30 first days after cardiac surgery * Patient not meeting the inclusion criteria

Locations (1)

Bordeaux University Hospital

Pessac, France

Outcomes

Primary Outcomes

Long-term renal outcome

Proportion of patients meeting a composite criterion : death or permanent dialysis or doubling the baseline serum creatinine value

Time frame: 12 months after surgery

Secondary Outcomes

Glomerular Filtration Rate (GFR)

Glomerular Filtration Rate (GFR) calculated with CKD-EPI formula

Time frame: 30 days after surgery

Glomerular Filtration Rate (GFR)

Glomerular Filtration Rate (GFR) calculated with CKD-EPI formula

Time frame: 12 months after surgery

Vital status

Mortality after surgery

Time frame: 12 months after surgery

Major Adverse Kidney Events

Major Adverse Kidney Events defined by new receipt of Renal replacement therapy (RRT), or Acute Kidney Injury (AKI) episodes with persistent renal dysfunction and final serum creatinine value before hospital discharge ≥ 200 % of the baseline serum creatinine

Time frame: Up to 12 months after surgery

Data from ClinicalTrials.gov

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