Function of Circulating Exosomes in Sepsis-induced Immunosuppression

Inclusion Criteria: * ≥ 50 years with ≥ 2 chronic comorbidities * Highly suspected bacterial infection based on clinical or radiologic evidence * ≥ 2 systemic inflammatory response syndrome (SIRS) criteria * Actual/anticipated admission to intensive care unit (ICU) * Anticipated length of hospital stay ≥ 5 days Exclusion Criteria: * Pregnancy * Underlying immunosuppression (solid organ transplant, hematopoietic stem cell transplant, neutropenia, HIV infection, long-term corticosteroid use (≥ 20 mg prednisone equivalents for ≥ 14 days), immunosuppressants, radiation, chemotherapy, immune-modifying biologics, viral hepatitis, or systemic autoimmune diseases) * Current immunotherapy use * Confirmed COVID-19 infection