Assessment of Kidney Function and Osteomuscular Status After Critical Care

University of Liege100 enrolled

Overview

This observational study aims to assess kidney function through direct glomerular filtration rate (GFR) using iohexol clearance, compared to estimated GFR based on creatinine and cystatin C equations. Kidney function will also be evaluated through renal fibrosis biomarkers. Kidney function will be correlated to body composition, muscle turnover biomarkers, and bone micro-architecture.

The investigators developed a post-ICU clinic where complications of the post-intensive care syndrome are detected. Muscle function is assessed by clinical testings, muscle strength measurement. Body composition is measured by electrical bioimpedance. Bone mass is assessed using dual-energy radiographic absorptiometry. It is well known that ICU survivors experience a loss of muscle mass. This can lead to misinterpretation of estimated GFR based on creatinine equations. The aim of the present study is to assess the evolution of kidney function after a prolonged stay in ICU, using GFR equations based on cystatin C, and to compare it to measured GFR using iohexol clearance. The second aim is to explore the evolution of bone and muscle health in these patients.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Critical Illness Kidney Injury Muscle Loss Bone Loss

Interventions

one-year follow-upOTHER

patients will be followed during the year after ICU discharge, in order to assess kidney function, and muscle and bone health

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients surviving an ICU stay of at least 7 days * patients who experienced acute kidney injury (KDIGO criteria) during ICU stay Exclusion Criteria: * chronic kidney injury with dedicated follow-up before ICU admission * chronic extrarenal epuration * kidney transplant * allergy to iohexol * iodinated contrast allergy * refusal

Locations (1)

University Hospital of Liège

Liège, Liège, Belgium

Outcomes

Primary Outcomes

measured GFR

plasma clearance of iohexol

Time frame: between day 0 and day 7 after ICU discharge

measured GFR

plasma clearance of iohexol

Time frame: at 3 months after ICU discharge

measured GFR

plasma clearance of iohexol

Time frame: at 12 months after ICU discharge

estimated GFR

cystatin C based CKD-EPI equation

Time frame: between day 0 and day 7 after ICU discharge

estimated GFR

cystatin C based CKD-EPI equation

Time frame: at 3 months after ICU discharge

estimated GFR

cystatin C based CKD-EPI equation

Time frame: at 12 months after ICU discharge