Intra-articular Injections of Platelet-rich Plasma, Hyaluronic Acid, or Corticosteroids for Knee Osteoarthritis

Inclusion Criteria: * Patient aged 35-65 years old * Patient with knee pain that had been continuing for at least 12 months with no relief using anti-inflammatory medications and that deteriorated with weight-bearing * Knee osteoarthritis that classified as mild-moderate or moderate-severe (Kellgren-Lawrence Grade 2, 3, or 4) Exclusion Criteria: * Age \> 65 years * The recent history of knee trauma * Autoimmune rheumatic diseases * Accompanying severe hip OA * Thrombocytopenia or other blood diseases * Immunosuppressive or anticoagulant treatment * The invasive procedure applied to the knee * Intra-articular steroid injection to the knee within the previous 12 months * Previous joint infection * Uncontrolled systemic diseases such as diabetes or hypertension, and cancer * Excessive varus/valgus knee deformity