Recent data suggest that gut microbiota can function as an environmental factor that modulates the amount of body fat and obese individuals have an altered gut microbiota.The results of previous animal studies have suggest that a probiotic strain Lactobacillus paracasei K56 have reduced high-fat diet induced obesity. In this before-after pilot study, the participants were randomly assigned to 8 groups to compare the fat-reducing effect of the Lactobacillus paracasei K56 by continuously supplementing different product prototypes , and screen the best probiotic K56 prototype with the effect of fat reduction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
118
Probiotic drink (K56 10\^11CFU) 350ml/d for 60days
maltodextrin ,for 60days
Probiotic powder 3.0g/d (K56 10\^10cfu) 60days;
probiotic powder 8g/day for 60days
probiotic k56 capsule, 2capsules/d (10\^7cfu) for 60days
probiotic k56 capsule, 2capsules/d (10\^9cfu) for 60days
probiotic k56 capsule, 2capsules/d (10\^10cfu) for 60days
probiotic k56 capsule, 4capsules/d (10\^11cfu) for 60days
Hua Dong Hospital Affiliated to Fu Dan University
Shanghai, China
percent body fat
percent body fat (%) will be assessed at baseline and after 60days of intervention
Time frame: 60days
visceral fat area
visceral fat area (cm\^2) will be assessed at baseline and after 60days of intervention
Time frame: 60days
Serum Lipid Profile
Serum total cholesterol(mmol/L)，Serum triglycerides(mmol/L)，Low-density lipoprotein(mmol/L)，High density lipoprotein(mmol/L) will be measured at baseline and after 60days of intervention
Time frame: 60 days
fasting blood glucose
fasting blood glucose(mmol/L) will be measured at baseline and after 60days of intervention
Time frame: 60 days
Glycated hemoglobin
Glycated hemoglobin(%) will be measured at baseline and after 60days of intervention
Time frame: 60 days
Glycosylated albumin
Glycosylated albumin(%) will be measured at baseline and after 60days of intervention
Time frame: 60 days
skeletal muscle mass
skeletal muscle mass (kg) will be assessed at baseline and after 60days of intervention
Time frame: 60 days
waist to hip ratio (WHR)
waist to hip ratio (WHR) will be assessed at baseline and after 60days of intervention
Time frame: 60 days
Body Mass Index BMI
Body Mass Index (kg/m\^2) will be assessed at baseline and after 60days of intervention
Time frame: 60 days
body weight
Body weight (kg) will be assessed at baseline and after 60days of intervention
Time frame: 60 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.